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GluRIIE Glutamate receptor IIE [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318623, updated on 9-Dec-2024

Summary

Official Symbol
GluRIIEprovided by FlyBase
Official Full Name
Glutamate receptor IIEprovided by FlyBase
Primary source
FLYBASE:FBgn0051201
Locus tag
Dmel_CG31201
See related
AllianceGenome:FB:FBgn0051201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31201; DmelGluRIIE; Dmel\CG31201; GluR-IIE
Summary
Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in abdominal ventral muscle cell; embryonic/larval hypodermal muscle cell; larval somatic muscle cell; and somatic muscle primordium. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See GluRIIE in Genome Data Viewer
Location:
92F4-92F4; 3-69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20644154..20648716, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16469876..16474438, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hairless Neighboring gene Phosphatidylinositol 3-kinase 92E Neighboring gene Leucine-rich repeat kinase Neighboring gene Glutamate receptor IID Neighboring gene Neprilysin 4 Neighboring gene Cuticular protein 92F

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neuromuscular synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of synaptic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic transmission, glutamatergic IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of ionotropic glutamate receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in muscle cell postsynaptic specialization IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glutamate receptor IIE
Names
CG31201-PB
GluRIIE-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20644154..20648716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043268.2NP_001036733.1  glutamate receptor IIE [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI42, Q5U165
    Conserved Domains (4) summary
    cd06382
    Location:42396
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    cd13714
    Location:419790
    PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
    pfam00060
    Location:551824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:51382
    ANF_receptor; Receptor family ligand binding region