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Qsox4 Quiescin sulfhydryl oxidase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318720, updated on 9-Dec-2024

Summary

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Official Symbol
Qsox4provided by FlyBase
Official Full Name
Quiescin sulfhydryl oxidase 4provided by FlyBase
Primary source
FLYBASE:FBgn0051413
Locus tag
Dmel_CG31413
See related
AllianceGenome:FB:FBgn0051413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10299; CG31413; Dmel\CG31413; QSox4
Summary
Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Predicted to be active in Golgi membrane and extracellular space. Is expressed in adult head. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Qsox4 in Genome Data Viewer
Location:
95A8-95A9; 3-80 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23702761..23704542)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19528483..19530264)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glucocerebrosidase 1a Neighboring gene Glucocerebrosidase 1b Neighboring gene antisense RNA:CR44052 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. Davis MY, et al. PLoS Genet, 2016 Mar. PMID 27019408, Free PMC Article
  2. Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks. Ayroles JF, et al. Genet Res (Camb), 2011 Dec. PMID 22189604, Free PMC Article
  3. Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. Sepil I, et al. Mol Cell Proteomics, 2019 Mar 15. PMID 30287546, Free PMC Article
  4. BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31740617, Free PMC Article
  5. The evolution of seminal fluid gene expression and postmating reproductive isolation in Drosophila. Flacchi C, et al. Evolution, 2024 May 1. PMID 38416119

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin-dependent sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin-dependent sulfhydryl oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin-dependent sulfhydryl oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
quiescin sulfhydryl oxidase 4
Names
CG31413-PA
Qsox4-PA
NP_732891.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23702761..23704542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170084.3 → NP_732891.1  quiescin sulfhydryl oxidase 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QV0, Q8IMY4
    Related
    FBpp0083834
    Conserved Domains (2) summary
    cd02992
    Location:32 → 145
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:425 → 512
    Evr1_Alr; Erv1 / Alr family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IMY4 Q8IMY4

Gene LinkOut

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