ric8a ric8a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ric8aprovided by FlyBase
Official Full Name: ric8aprovided by FlyBase
Primary source: FLYBASE:FBgn0028292
Locus tag: Dmel_CG15797
See related: AllianceGenome:FB:FBgn0028292
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15797; Dmel\CG15797; DmRic8; l(1)G0397; ric-8; Ric-8; RIC-8; ric-8a; Ric-8A; Ric8a
Summary: Enables G-protein alpha-subunit binding activity. Involved in several processes, including establishment of mitotic spindle localization; gastrulation involving germ band extension; and protein stabilization. Located in cytosol; type Ib terminal bouton; and type Is terminal bouton. Is expressed in organism. Orthologous to several human genes including RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 8D3-8D3; 1-27 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9256168..9259202)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9150201..9153235)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neomorphic Galphao mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
Title: Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
the small molecule stabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.
Title: Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Data indicate that Ric-8 binds to Galpha12/13 subunit, Concertina (Cta) through an interface of conserved residues.
Title: Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway.
New studies show that targeting of G-protein subunits to membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and independent pathways.
Title: Drosophila G-protein signalling: intricate roles for Ric-8?
Ric-8 homologue is required for asymmetric division of both NBs and pl cells.Ric-8 is necessary for membrane targeting of Galphai, Pins and Gbeta13F
Title: Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.
both receptor-dependent and receptor-independent G-protein functions are executed at the plasma membrane and require the Ric-8 protein.
Title: Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins.
Ric-8, which belongs to a family of guanine nucleotide-exchange factors for Galphai, regulates cortical localization of the subunits Galphai and Gbeta13F.
Title: Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation involving germ band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in type Ib terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in type Is terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ric8a

Names: CG15797-PA; CG15797-PB; ric8a-PA; ric8a-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9256168..9259202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298119.1 → NP_001285048.1 ric8a, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285048.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W358

UniProtKB/TrEMBL

X2JEL4

Conserved Domains (1) summary

pfam10165
Location:67 → 548

Ric8; Guanine nucleotide exchange factor synembryn
NM_132322.4 → NP_572550.2 ric8a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572550.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W358

UniProtKB/TrEMBL

X2JEL4

Related

FBpp0071252

Conserved Domains (1) summary

pfam10165
Location:67 → 548

Ric8; Guanine nucleotide exchange factor synembryn