Erk7 Extracellularly regulated kinase 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Erk7provided by FlyBase
Official Full Name: Extracellularly regulated kinase 7provided by FlyBase
Primary source: FLYBASE:FBgn0052703
Locus tag: Dmel_CG32703
See related: AllianceGenome:FB:FBgn0052703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17441; CG2309; CG32703; Dmel\CG32703; erk; Erk; ERK; ERK7
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; cilium assembly; and negative regulation of cell size. Located in ciliary basal body; endoplasmic reticulum membrane; and nuclear envelope. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 8D3-8D4; 1-27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9261376..9267698, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9155409..9161731, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we conclude that a cell autonomous ribosome surveillance response, which leads to upregulation of ERK7, inhibits dILP secretion to impede tissue growth under limiting dietary conditions.
Title: p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion.
In response to amino acid starvation, ERK7-mediated post-translational modification elicits the cytoplasmic dispersion of Sec16 and the consequent disassembly of the ER exit sites, which in turn results in protein secretion inhibition.
Title: ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary transition zone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: extracellularly regulated kinase 7

Names: CG32703-PA; CG32703-PB; CG32703-PC; Erk7-PA; Erk7-PB; Erk7-PC

NP_001188568.1

EC 2.7.11.1

EC 2.7.11.24

NP_001188569.1

EC 2.7.11.1

EC 2.7.11.24

NP_727335.1

EC 2.7.11.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9261376..9267698 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201639.1 → NP_001188568.1 extracellularly regulated kinase 7, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188568.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MSN4, Q9W354

Conserved Domains (1) summary

cd07852
Location:17 → 358

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
NM_167188.2 → NP_727335.1 extracellularly regulated kinase 7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727335.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MSN4, Q9W354

Related

FBpp0071264

Conserved Domains (1) summary

cd07852
Location:17 → 358

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
NM_001201640.2 → NP_001188569.1 extracellularly regulated kinase 7, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188569.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSN4

Conserved Domains (2) summary

smart00220
Location:25 → 319

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:17 → 358

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs