lz lozenge [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lzprovided by FlyBase
Official Full Name: lozengeprovided by FlyBase
Primary source: FLYBASE:FBgn0002576
Locus tag: Dmel_CG1689
See related: AllianceGenome:FB:FBgn0002576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: amx; CG1689; Dmel\CG1689; fs(1)A1569; fs(1)M69; Lozenge; Lz; LZ; spe
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including compound eye morphogenesis; embryonic crystal cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adult antennal sensillum; adult olfactory antennal lobe glomerulus; eye photoreceptor cell; hemocyte; and imaginal disc. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 8D5-8D6; 1-27 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9284649..9303636)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9178682..9197669)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster has been reported.
Title: Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster.
our data indicate that the MLF/DnaJ-1-dependent increase in Lz level allows the repression of Notch expression and signaling to prevent aberrant blood cell development. Thus our findings establish a functional link between MLF and the co-chaperone DnaJ-1 to control RUNX transcription factor activity and Notch signaling during blood cell development in vivo.
Title: Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis.
Lz provides key intrinsic information to cells during the second wave of pattern formation in the developing ommatidium.
Title: Switching cell fates in the developing Drosophila eye.
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.
Title: Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.
mlf participates in a positive feedback loop to fine tune the activity of the RUNX transcription factor Lozenge (LZ) during development of the crystal cells.
Title: Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.
Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture.
Title: A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
Results lead to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila.
Title: Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc.
Results show that the GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development.
Title: The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development.
Glial cells missing (GCM)/GCM2 play a key role in controlling the size of the crystal cell population by inhibiting lz activation and maintenance
Title: Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors.
Lz can trigger crystal cell development.
Title: Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antennal development	TAS Traceable Author Statement more info	PubMed
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic crystal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of crystal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in scab formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in spermathecum morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed