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Gga Golgi-localized, gamma-adaptin ear containing, ARF binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31902, updated on 9-Dec-2024

Summary

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Official Symbol
Ggaprovided by FlyBase
Official Full Name
Golgi-localized, gamma-adaptin ear containing, ARF binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030141
Locus tag
Dmel_CG3002
See related
AllianceGenome:FB:FBgn0030141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3002; dGGA; Dmel\CG3002; dmGGA; DmGGA1; GGA
Summary
Enables clathrin adaptor activity and clathrin heavy chain binding activity. Involved in post-Golgi vesicle-mediated transport. Located in several cellular components, including clathrin-coated vesicle; perinuclear region of cytoplasm; and trans-Golgi network. Is expressed in several structures, including adult brain cell body rind; adult mushroom body beta-lobe; anterior-posterior subdivision of organism; male germline cell; and retina. Used to study lysosomal storage disease and neurodegenerative disease. Orthologous to several human genes including GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1) and GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gga in Genome Data Viewer
Location:
8F1-8F1; 1-29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9601030..9604280)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9495063..9498313)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45542 Neighboring gene long non-coding RNA:CR45543 Neighboring gene Lst8 Neighboring gene Lysyl-tRNA synthetase Neighboring gene Hecw ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors. Dennes A, et al. J Biol Chem, 2005 Apr 1. PMID 15664992
  2. The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. Luan S, et al. PLoS One, 2012. PMID 23028818, Free PMC Article
  3. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. Hirst J, et al. BMC Cell Biol, 2011 May 20. PMID 21599933, Free PMC Article
  4. Drosophila GGA model: an ultimate gateway to GGA analysis. Eissenberg JC, et al. Traffic, 2011 Dec. PMID 21923734, Free PMC Article
  5. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. Kametaka S, et al. J Cell Sci, 2010 Feb 1. PMID 20067992, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homozygous and hemizygous flies for the mutatited GGA allele are viable and fertile.
    Title: The unique GGA clathrin adaptor of Drosophila melanogaster is not essential.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables clathrin adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables clathrin heavy chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in post-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi-localized, gamma-adaptin ear containing, ARF binding protein
Names
CG3002-PB
Gga-PB
Golgi-localised, gamma-ear containing, ADP ribosylation factor-binding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9601030..9604280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132343.4 → NP_572571.1  Golgi-localized, gamma-adaptin ear containing, ARF binding protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TM1, Q9W329
    Related
    FBpp0071298
    Conserved Domains (3) summary
    smart00809
    Location:543 → 644
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:7 → 144
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    pfam03127
    Location:210 → 284
    GAT; GAT domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RK8 Q95RK8
Q9W329 Q9W329

Gene LinkOut

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