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LysRS Lysyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31904, updated on 4-Jan-2025

Summary

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Official Symbol
LysRSprovided by FlyBase
Official Full Name
Lysyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027084
Locus tag
Dmel_CG12141
See related
AllianceGenome:FB:FBgn0027084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aats-lys; CG12141; dKARS; Dmel\CG12141; KRS
Summary
Predicted to enable lysine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in lysyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; germline cell; and gut section. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See LysRS in Genome Data Viewer
Location:
8F1-8F1; 1-29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9606363..9608884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9500396..9502917, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45543 Neighboring gene Golgi-localized, gamma-adaptin ear containing, ARF binding protein Neighboring gene Lst8 Neighboring gene Hecw ubiquitin protein ligase Neighboring gene Protein tyrosine phosphatase Meg2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript. Tolkunova E, et al. J Biol Chem, 2000 Nov 10. PMID 10952987
  2. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
  3. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
  4. Mixture modeling of transcript abundance classes in natural populations. Hsieh WP, et al. Genome Biol, 2007. PMID 17547747, Free PMC Article
  5. Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis. Palu RAS, et al. G3 (Bethesda), 2019 Dec 3. PMID 31570502, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables lysine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lysyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lysyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Lysyl-tRNA synthetase
Names
CG12141-PA
CG12141-PB
CG12141-PC
LysRS-PA
LysRS-PB
LysRS-PC
kars
NP_001188571.1
NP_572573.1
NP_727353.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9606363..9608884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132345.2 → NP_572573.1  Lysyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H7Z0, Q8SXM8
    Related
    FBpp0071301
    Conserved Domains (3) summary
    PLN02502
    Location:1 → 560
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:220 → 558
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:108 → 217
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

  2. NM_001201642.2 → NP_001188571.1  Lysyl-tRNA synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H7Z0, Q9W327
    Conserved Domains (3) summary
    PLN02502
    Location:42 → 593
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:253 → 591
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:141 → 250
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

  3. NM_167196.3 → NP_727353.1  Lysyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727353.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H7Z0, Q9W327
    Related
    FBpp0071302
    Conserved Domains (3) summary
    PLN02502
    Location:42 → 593
    PLN02502; lysyl-tRNA synthetase
    cd00775
    Location:253 → 591
    LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
    cd04322
    Location:141 → 250
    LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXM8 Q8SXM8
Q9W327 Q9W327

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