U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sf3b2 splicing factor 3b, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 319322, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Sf3b2provided by MGI
Official Full Name
splicing factor 3b, subunit 2provided by MGI
Primary source
MGI:MGI:2441856
See related
Ensembl:ENSMUSG00000024853 AllianceGenome:MGI:2441856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SF3b1; 145kDa; SAP145; SF3b145; SF3b150; 2610311M13Rik; 2810441F20Rik; B230398H18Rik
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in early conceptus; inner cell mass; and oocyte. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 77.1), CNS E14 (RPKM 51.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sf3b2 in Genome Data Viewer
Location:
19 A; 19 4.29 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5323949..5345485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5273921..5295457, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene phosphofurin acidic cluster sorting protein 1 Neighboring gene STARR-seq mESC enhancer starr_45376 Neighboring gene STARR-seq mESC enhancer starr_45378 Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene predicted gene, 42064 Neighboring gene RNA polymerase II associated protein 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis. Jeong YE, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36574260, Free PMC Article
  2. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Murphy SA, et al. Nat Commun, 2021 Mar 12. PMID 33712605, Free PMC Article
  3. Identification of novel Smad binding proteins. Warner DR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651998
  4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis.
    Title: Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis.
  2. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
    Title: PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type precatalytic spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
splicing factor 3B subunit 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362454.1 → NP_001349383.1  splicing factor 3B subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125059, CD776683
    Conserved Domains (3) summary
    smart00581
    Location:583 → 641
    PSP; proline-rich domain in spliceosome associated proteins
    pfam02037
    Location:24 → 57
    SAP; SAP domain
    pfam04037
    Location:453 → 578
    DUF382; Domain of unknown function (DUF382)

  2. NM_030109.2 → NP_084385.2  splicing factor 3B subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_084385.2

    Status: VALIDATED

    Source sequence(s)
    AK146063, BI134679, BY785284
    Consensus CDS
    CCDS29454.1
    UniProtKB/Swiss-Prot
    A0A494B9S9, Q3UAI4, Q3UBH2, Q3UJB0, Q3UQU5, Q80W39, Q8BL33, Q9CS24
    Related
    ENSMUSP00000025774.10, ENSMUST00000025774.11
    Conserved Domains (3) summary
    smart00581
    Location:584 → 642
    PSP; proline-rich domain in spliceosome associated proteins
    pfam02037
    Location:24 → 57
    SAP; SAP domain
    pfam04037
    Location:454 → 579
    DUF382; Domain of unknown function (DUF382)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5323949..5345485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJB0.1 GenPept UniProtKB/Swiss-Prot:Q3UJB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous