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Yp1 Yolk protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31939, updated on 9-Dec-2024

Summary

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Official Symbol
Yp1provided by FlyBase
Official Full Name
Yolk protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0004045
Locus tag
Dmel_CG2985
See related
AllianceGenome:FB:FBgn0004045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2985; Dmel\CG2985; DmYP1; fs(1)1163; fs(1)A1163; VG1; VIT1Dm; yp; YP; yp-1; YP-1; yp1; YP1; YPI; YP[[1]]
Summary
Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adult fat body; adult head; antennal primordium; embryonic antennal sense organ; and sperm storage organ. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Yp1 in Genome Data Viewer
Location:
9A5-9A5; 1-30 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10053811..10055498)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9947844..9949531)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Chitinase 6 Neighboring gene antisense RNA:CR45185 Neighboring gene antisense RNA:CR45601 Neighboring gene Yolk protein 2 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 9a Neighboring gene long non-coding RNA:CR45602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries. Bownes M, et al. Insect Mol Biol, 2002 Oct. PMID 12230547
  2. Insect population control using female specific pro-drug activation. Markaki M, et al. Insect Biochem Mol Biol, 2004 Feb. PMID 14871609
  3. Developmental regulation of yolk protein gene expression in Anastrepha suspensa. Handler AM. Arch Insect Biochem Physiol, 1997. PMID 9243791
  4. Effects of Food and Temperature on Drosophila melanogaster Reproductive Dormancy as Revealed by Quantification of a GFP-Tagged Yolk Protein in the Ovary. Hara Y, et al. Front Physiol, 2021. PMID 35046840, Free PMC Article
  5. A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program. Heinrich JC, et al. Proc Natl Acad Sci U S A, 2000 Jul 18. PMID 10890889, Free PMC Article

See all (246) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of all YP1, YP2 and YP3 genes was shown to be a unique feature of testis tissues.
    Title: Yolk proteins in the male reproductive system of the fruit fly Drosophila melanogaster: spatial and temporal patterns of expression.
  2. Yp (Yolk protein) expression is significantly negatively correlated with longevity, an important life history trait, for both males and females.
    Title: Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.
  3. cloned the Drosophila yp1 gene into an E. coli expression vector and showed that the yolk protein produced by E. coli is taken up into ovaries of both Drosophila melanogaster and the malaria mosquito Anopheles gambiae
    Title: Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables lipase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sex differentiation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
yolk protein 1
Names
CG2985-PA
CG2985-PB
Yok protein 1
Yp1-PA
Yp1-PB
vitellogenin
yolk protein
yolk protein I
yolk-protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10053811..10055498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298142.1 → NP_001285071.1  yolk protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285071.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02843, Q8SXV7, Q9W2Y9
    UniProtKB/TrEMBL
    Q29QE3, X2JD55
    Conserved Domains (1) summary
    cl21494
    Location:183 → 406
    Abhydrolase; alpha/beta hydrolases

  2. NM_078548.3 → NP_511103.1  yolk protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02843, Q8SXV7, Q9W2Y9
    UniProtKB/TrEMBL
    Q29QE3, X2JD55
    Related
    FBpp0071354
    Conserved Domains (1) summary
    cl21494
    Location:183 → 406
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02843.1 P02843
X2JD55 X2JD55

Gene LinkOut

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