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RhoU RhoU [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31945, updated on 4-Jan-2025

Summary

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Official Symbol
RhoUprovided by FlyBase
Official Full Name
RhoUprovided by FlyBase
Primary source
FLYBASE:FBgn0083940
Locus tag
Dmel_CG34104
See related
AllianceGenome:FB:FBgn0083940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12094; CG12102; CG34104; Dmel\CG34104
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including antennal anlage; antennal primordium; gut section; head epidermis primordium; and somatic trunk mesoderm derivative. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See RhoU in Genome Data Viewer
Location:
9B1-9B2; 1-31 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10086527..10148876)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9980560..10042909)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ZAP3 Neighboring gene uncharacterized protein Neighboring gene NAD(P)HX epimerase Neighboring gene antisense RNA:CR44894 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stripy Ftz target genes are coordinately regulated by Ftz-F1. Hou HY, et al. Dev Biol, 2009 Nov 15. PMID 19679121, Free PMC Article
  2. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
  3. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
  4. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
  5. Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures. Sytnikova YA, et al. Genome Res, 2014 Dec. PMID 25267525, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: 10095218-10101092 mobile_element_type = transposon:297{}93
  • Loc: 10138270-10145710 mobile_element_type = transposon:412{}95

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RhoU
Names
CG34104-PA
CG34104-PB
CG34104-PC
RhoU-PA
RhoU-PB
RhoU-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10086527..10148876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042801.2 → NP_001036266.1  RhoU, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHU4
    Conserved Domains (2) summary
    cd04130
    Location:393 → 562
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
    smart00174
    Location:395 → 559
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

  2. NM_001298144.1 → NP_001285073.1  RhoU, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285073.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHU4
    Conserved Domains (2) summary
    cd04130
    Location:393 → 562
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
    smart00174
    Location:395 → 559
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

  3. NM_001042802.2 → NP_001036267.1  RhoU, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXY7, Q9W2Y2
    Conserved Domains (1) summary
    cl21455
    Location:393 → 431
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHU4 Q0KHU4
Q8SXY7 Q8SXY7

Gene LinkOut

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