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Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Mus musculus (house mouse) ]

Gene ID: 319518, updated on 27-Nov-2024

Summary

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Official Symbol
Pdprprovided by MGI
Official Full Name
pyruvate dehydrogenase phosphatase regulatory subunitprovided by MGI
Primary source
MGI:MGI:2442188
See related
Ensembl:ENSMUSG00000033624 AllianceGenome:MGI:2442188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1990; 4930402E16Rik
Summary
Located in mitochondrion. Is expressed in cerebral cortex; heart; and liver. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 14.4), kidney adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pdpr in Genome Data Viewer
Location:
8 E1; 8 57.95 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111821232..111866402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111094609..111139781)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene STARR-seq mESC enhancer starr_22692 Neighboring gene STARR-positive B cell enhancer ABC_E708 Neighboring gene predicted gene, 53455 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene STARR-seq mESC enhancer starr_22693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. He H, et al. Nat Commun, 2024 Sep 16. PMID 39284798, Free PMC Article
  2. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
NP_938050.1
XP_006531147.1
XP_030099464.1
XP_036009980.1
XP_036009981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198308.1 → NP_938050.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_938050.1

    Status: PROVISIONAL

    Source sequence(s)
    AY223867
    Consensus CDS
    CCDS22670.1
    UniProtKB/Swiss-Prot
    Q6ZPF5, Q7TSQ8
    Related
    ENSMUSP00000046639.4, ENSMUST00000039333.10
    Conserved Domains (2) summary
    COG0404
    Location:452 → 867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:38 → 425
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111821232..111866402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531084.5 → XP_006531147.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531147.1

    UniProtKB/Swiss-Prot
    Q6ZPF5, Q7TSQ8
    Conserved Domains (2) summary
    COG0404
    Location:452 → 867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:38 → 425
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  2. XM_036154087.1 → XP_036009980.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

    UniProtKB/TrEMBL
    D6RD07
    Related
    ENSMUSP00000121325.2, ENSMUST00000144377.2
    Conserved Domains (3) summary
    pfam01266
    Location:44 → 384
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:462 → 688
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam16350
    Location:405 → 459
    FAO_M; FAD dependent oxidoreductase central domain

  3. XM_036154088.1 → XP_036009981.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (2) summary
    COG0404
    Location:51 → 466
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam16350
    Location:4 → 58
    FAO_M; FAD dependent oxidoreductase central domain

  4. XM_030243604.2 → XP_030099464.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (2) summary
    COG0404
    Location:51 → 466
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam16350
    Location:4 → 58
    FAO_M; FAD dependent oxidoreductase central domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSQ8.1 GenPept UniProtKB/Swiss-Prot:Q7TSQ8

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