Dusp4 dual specificity phosphatase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp4provided by MGI
Official Full Name: dual specificity phosphatase 4provided by MGI
Primary source: MGI:MGI:2442191
See related: Ensembl:ENSMUSG00000031530 AllianceGenome:MGI:2442191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MKP2; 2700078F24Rik; E130306H24Rik
Summary: Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in several processes, including dephosphorylation; endoderm formation; and negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; olfactory epithelium; and unsegmented mesenchyme. Orthologous to human DUSP4 (dual specificity phosphatase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 27.6), CNS E14 (RPKM 24.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 21.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (35274448..35289106)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (34807610..34819894)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response.
Title: DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response.
Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease.
Title: Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease.
Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.
Title: Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.
DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90beta.
Title: DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β.
Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces beta-Amyloid Load in Males and Females.
Title: Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females.
Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease.
Title: Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease.
Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing.
Title: Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing.
MKP-2 has the potential to play a major role in regulating RA due to a direct effect on neutrophil function, with the potential to effect macrophages, osteoclast formation and bone development.
Title: Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis.
Dusp4 was found to be expressed in skeletal muscle and plays a role in the regulation of muscle cell differentiation.
Title: Dual-specificity phosphatase 4 is upregulated during skeletal muscle atrophy and modulates extracellular signal-regulated kinase activity.
Transcriptome profiling reveals that MKP-2 regulates macrophage development showing candidate targets from monocyte-to-macrophage differentiation and macrophage proliferation. However, it is unclear whether effects upon ERK signalling are able to explain the effects of DUSP-4 deletion on macrophage function.
Title: Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI844617 (e-PCR)
- UniSTS:179729

AA997460 (e-PCR)
- UniSTS:248414

NoName (e-PCR)
- UniSTS:235871

BB104621 (e-PCR)
- UniSTS:185753

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoderm formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity protein phosphatase 4

NP_001398513.1

EC 3.1.3.16

EC 3.1.3.48

NP_795907.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411584.1 → NP_001398513.1 dual specificity protein phosphatase 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC122458
NM_176933.5 → NP_795907.1 dual specificity protein phosphatase 4 isoform 1

See identical proteins and their annotated locations for NP_795907.1

Status: VALIDATED

Source sequence(s)

AC122458

Consensus CDS

CCDS22241.1

UniProtKB/Swiss-Prot

Q8BFV3

UniProtKB/TrEMBL

Q0VF80

Related

ENSMUSP00000033930.5, ENSMUST00000033930.5

Conserved Domains (2) summary

cd00127
Location:199 → 335

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:9 → 162

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...