Mpzl3 myelin protein zero-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpzl3provided by MGI
Official Full Name: myelin protein zero-like 3provided by MGI
Primary source: MGI:MGI:2442647
See related: Ensembl:ENSMUSG00000070305 AllianceGenome:MGI:2442647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rc; ruf; 5430427F17Rik; A530065I17Rik
Summary: Acts upstream of or within extracellular matrix organization and hair cycle. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MPZL3 (myelin protein zero like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 4.2), small intestine adult (RPKM 3.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44966479..44988735)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45055181..45077437)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.
Title: Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.
Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.
Title: Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.
Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling.
Title: Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling.
MPZL3 and IL17 may have a role in the pathogenesis of seborrhoeic dermatitis-like skin inflammation.
Title: Increased IL-17-expressing γδ T cells in seborrhoeic dermatitis-like lesions of the Mpzl3 knockout mice.
ZNF750/MPZL3 pathway plays a critical role in the pathogenesis of seborrheic dermatitis
Title: Loss of MPZL3 function causes seborrhoeic dermatitis-like phenotype in mice.
Mpzl3 has a novel physiological role in controlling body weight regulation, energy expenditure, glycemic control, and hepatic triglyceride synthesis in mice
Title: Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis.
novel gene encoding a predicted adhesion protein whose mutation in the rc/rc mice likely caused the rc phenotype
Title: Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities.

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Phenotypes

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Associated conditions

Description	Tests
rough coat GeneReviews: Not available
rough fur GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Spontaneous (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myelin protein zero-like protein 3

Names: Ig-like domain-containing protein UNQ2966

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093749.3 → NP_001087218.1 myelin protein zero-like protein 3 precursor

See identical proteins and their annotated locations for NP_001087218.1

Status: VALIDATED

Source sequence(s)

AC122305, EF102773

Consensus CDS

CCDS52781.1

UniProtKB/Swiss-Prot

A5H7F1, Q3V3F6

Related

ENSMUSP00000110312.3, ENSMUST00000114664.8

Conserved Domains (2) summary

smart00410
Location:40 → 148

IG_like; Immunoglobulin like

cl11960
Location:34 → 137

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44966479..44988735

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_176993.3: Suppressed sequence

Description

NM_176993.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.