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Vago vago [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32040, updated on 9-Dec-2024

Summary

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Official Symbol
Vagoprovided by FlyBase
Official Full Name
vagoprovided by FlyBase
Primary source
FLYBASE:FBgn0030262
Locus tag
Dmel_CG2081
See related
AllianceGenome:FB:FBgn0030262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH70969; CG2081; DIGF-2; Dmel\CG2081; vago; VAGO
Summary
Involved in defense response to virus. Predicted to be located in extracellular space. Is expressed in adult fat body and adult heart. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vago in Genome Data Viewer
Location:
10A4-10A4; 1-33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11089290..11090219)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10983323..10984252)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sevenless Neighboring gene antisense RNA:CR44358 Neighboring gene antisense RNA:CR45604 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nora Virus VP4b and ORF1 Circulate in Hemolymph of Infected D. melanogaster with Coordinate Expression of Vago and Vir-1. Macke A, et al. Vaccines (Basel), 2020 Aug 31. PMID 32878003, Free PMC Article
  2. Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects. Poirier EZ, et al. Cell Host Microbe, 2018 Mar 14. PMID 29503180, Free PMC Article
  3. Origins and diversification of animal innate immune responses against viral infections. Iwama RE, et al. Nat Ecol Evol, 2023 Feb. PMID 36635343
  4. Contact-based sequence alignment. Kleinjung J, et al. Nucleic Acids Res, 2004. PMID 15121903, Free PMC Article
  5. Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster. Mongelli V, et al. Nat Ecol Evol, 2022 May. PMID 35273366, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in defense response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
vago
Names
CG2081-PB
CG2081-PD
Vago-PB
Vago-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11089290..11090219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298177.1 → NP_001285106.1  vago, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D2NUJ3, Q8MYS7, Q9VZ35
    Conserved Domains (1) summary
    pfam15430
    Location:41 → 106
    SVWC; Single domain von Willebrand factor type C

  2. NM_132452.3 → NP_572680.1  vago, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572680.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D2NUJ3, Q8MYS7, Q9VZ35
    Related
    FBpp0073283
    Conserved Domains (1) summary
    pfam15430
    Location:41 → 106
    SVWC; Single domain von Willebrand factor type C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZ35.1 Q9VZ35

Gene LinkOut

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