U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rpt3 Regulatory particle triple-A ATPase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32047, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Rpt3provided by FlyBase
Official Full Name
Regulatory particle triple-A ATPase 3provided by FlyBase
Primary source
FLYBASE:FBgn0028686
Locus tag
Dmel_CG16916
See related
AllianceGenome:FB:FBgn0028686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
16916; CG16916; Dmel\CG16916; Dmp48A; Dm_Rpt3a; l(1)G0052; p48A; rpt3; S6; S6B; TBP7
Summary
Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in male germ cell nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Used to study neurodegenerative disease. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rpt3 in Genome Data Viewer
Location:
10A6-10A6; 1-33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11125101..11126785)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11019134..11020818)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 60A Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle receptor alpha Neighboring gene Kinesin-like protein at 10A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Adám G, et al. Gene Expr Patterns, 2004 May. PMID 15053983
  2. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. Watson MR, et al. J Biol Chem, 2008 Sep 5. PMID 18596033, Free PMC Article
  3. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017
  4. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263
  5. Evolution of proteasomal ATPases. Wollenberg K, et al. Mol Biol Evol, 2001 Jun. PMID 11371584

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
regulatory particle triple-A ATPase 3
Names
CG16916-PA
CG16916-PB
Rpt3-PA
Rpt3-PB
NP_001285108.1
NP_572686.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11125101..11126785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298179.1 → NP_001285108.1  regulatory particle triple-A ATPase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1UIA5, Q9V405
    Conserved Domains (2) summary
    PTZ00454
    Location:22 → 413
    PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
    pfam00004
    Location:197 → 330
    AAA; ATPase family associated with various cellular activities (AAA)

  2. NM_132458.3 → NP_572686.1  regulatory particle triple-A ATPase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572686.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1UIA5, Q9V405
    Related
    FBpp0073292
    Conserved Domains (2) summary
    PTZ00454
    Location:22 → 413
    PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
    pfam00004
    Location:197 → 330
    AAA; ATPase family associated with various cellular activities (AAA)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V405 Q9V405

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous