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Tmem215 transmembrane protein 215 [ Mus musculus (house mouse) ]

Gene ID: 320500, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem215provided by MGI
Official Full Name
transmembrane protein 215provided by MGI
Primary source
MGI:MGI:2444167
See related
Ensembl:ENSMUSG00000046593 AllianceGenome:MGI:2444167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930001M12Rik
Summary
Acts upstream of or within negative regulation of retinal cell programmed cell death and sprouting angiogenesis. Predicted to be located in membrane. Orthologous to human TMEM215 (transmembrane protein 215). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 2.1), spleen adult (RPKM 1.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem215 in Genome Data Viewer
Location:
4 A5; 4 20.28 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40472180..40475653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40472180..40475653)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930509K18 gene Neighboring gene STARR-seq mESC enhancer starr_09985 Neighboring gene RIKEN cDNA 4933428C19 gene Neighboring gene predicted gene, 23338 Neighboring gene STARR-seq mESC enhancer starr_09986 Neighboring gene STARR-seq mESC enhancer starr_09987 Neighboring gene STARR-positive B cell enhancer ABC_E2688 Neighboring gene aprataxin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival. Liu Y, et al. J Cell Physiol, 2019 Jun. PMID 30370660, Free PMC Article
  2. Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Park KU, et al. Invest Ophthalmol Vis Sci, 2017 Feb 1. PMID 28199486, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results identified TMEM215 as a novel molecule involved in angiogenesis by regulating the survival of endothelial cells.
    Title: Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 215

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166009.1 → NP_001159481.1  transmembrane protein 215

    See identical proteins and their annotated locations for NP_001159481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL844182
    Consensus CDS
    CCDS18046.1
    UniProtKB/Swiss-Prot
    A7E1Z1, Q8C8R5
    UniProtKB/TrEMBL
    B7ZN35
    Related
    ENSMUSP00000136595.2, ENSMUST00000179526.2
    Conserved Domains (1) summary
    pfam15746
    Location:1 → 235
    TMEM215; TMEM215 family

  2. NM_177175.4 → NP_796149.2  transmembrane protein 215

    See identical proteins and their annotated locations for NP_796149.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK044627, CK617308
    Consensus CDS
    CCDS18046.1
    UniProtKB/Swiss-Prot
    A7E1Z1, Q8C8R5
    UniProtKB/TrEMBL
    B7ZN35
    Related
    ENSMUSP00000052129.3, ENSMUST00000049655.3
    Conserved Domains (1) summary
    pfam15746
    Location:1 → 235
    TMEM215; TMEM215 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40472180..40475653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7E1Z1.1 GenPept UniProtKB/Swiss-Prot:A7E1Z1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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