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Dlic Dynein light intermediate chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32057, updated on 9-Dec-2024

Summary

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Official Symbol
Dlicprovided by FlyBase
Official Full Name
Dynein light intermediate chainprovided by FlyBase
Primary source
FLYBASE:FBgn0030276
Locus tag
Dmel_CG1938
See related
AllianceGenome:FB:FBgn0030276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1938; D-LIC; dlic; DLIC; dlic2; Dlic2; DLIC2; Dmel\CG1938; l(1)G0065; l(1)G0190
Summary
Predicted to enable dynein heavy chain binding activity. Involved in several processes, including lumen formation, open tracheal system; mRNA transport; and neuron projection morphogenesis. Located in cytoplasm. Part of cytoplasmic dynein complex. Colocalizes with centrosome and nuclear envelope. Is expressed in adult head; oocyte; and organism. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1) and DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dlic in Genome Data Viewer
Location:
10A8-10A8; 1-33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11154421..11164670)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11048454..11058703)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ran Neighboring gene l(3)mbt interacting protein 1 Neighboring gene retroactive Neighboring gene uncharacterized protein Neighboring gene Antennal dehydrogenase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells. Even I, et al. FEBS J, 2019 Feb. PMID 30657258
  2. The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA. Soundararajan HC, et al. Elife, 2014 Apr 15. PMID 24737859, Free PMC Article
  3. A central neural pathway controlling odor tracking in Drosophila. Slater G, et al. J Neurosci, 2015 Feb 4. PMID 25653345, Free PMC Article
  4. Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function. Menant A, et al. Biol Cell, 2020 Oct. PMID 32602944
  5. Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, et al. Nat Cell Biol, 2012 Feb 26. PMID 22366687, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results point to a connection between membrane trafficking and dynein-mediated transport to sustain PAR3 asymmetry.
    Title: Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution.
  2. RNA interference depletion of Dlic in Drosophila S2 cells does not block the recruitment of a dynein complex to kinetochores, but it does delay inactivation of Mad2 signaling and mitotic progression.
    Title: Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation.
  3. These results reveal an important link between microtubule motors and endosomes in dendrite morphogenesis.
    Title: Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle HMP PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein light intermediate chain
Names
CG1938-PA
CG1938-PB
CG1938-PD
Dlic-PA
Dlic-PB
Dlic-PD
Dlic2
DyneinLC
dandelion clock
dynein light interme- diate chain
dynein light intermediate chain 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11154421..11164670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167274.2 → NP_727501.1  dynein light intermediate chain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U53, Q9VZ20
    Related
    FBpp0073299
    Conserved Domains (2) summary
    cd00267
    Location:43 → 79
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    pfam05783
    Location:25 → 493
    DLIC; Dynein light intermediate chain (DLIC)

  2. NM_132466.3 → NP_572694.1  dynein light intermediate chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572694.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U53, Q9VZ20
    Related
    FBpp0073297
    Conserved Domains (2) summary
    cd00267
    Location:43 → 79
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
    pfam05783
    Location:25 → 493
    DLIC; Dynein light intermediate chain (DLIC)

  3. NM_167276.2 → NP_727503.1  dynein light intermediate chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727503.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR93
    Related
    FBpp0073300
    Conserved Domains (1) summary
    pfam05783
    Location:1 → 398
    DLIC; Dynein light intermediate chain (DLIC)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR93 Q8IR93
Q9VZ20 Q9VZ20

Gene LinkOut

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