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GCS1 Glucosidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32073, updated on 9-Dec-2024

Summary

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Official Symbol
GCS1provided by FlyBase
Official Full Name
Glucosidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030289
Locus tag
Dmel_CG1597
See related
AllianceGenome:FB:FBgn0030289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1597; Dmel\CG1597
Summary
Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See GCS1 in Genome Data Viewer
Location:
10B3-10B3; 1-34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11344506..11348001, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11238539..11242034, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene Kinesin associated protein 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Characterization of a Venom Protein Calreticulin in the Ectoparasitoid Pachycrepoideus vindemiae. Yang L, et al. Insects, 2019 Dec 31. PMID 31906042, Free PMC Article
  2. Effects of lamellolysin from a parasitoid wasp on Drosophila blood cells in vitro. Rizki RM, et al. J Exp Zool, 1991 Feb. PMID 1899269
  3. Microtubule inhibitors block the morphological changes induced in Drosophila blood cells by a parasitoid wasp factor. Rizki RM, et al. Experientia, 1990 Mar 15. PMID 2311722
  4. Developmental analysis of a temperature-sensitive melanotic tumor mutant inDrosophila melanogaster. Rizki TM, et al. Wilehm Roux Arch Dev Biol, 1980 Oct. PMID 28305175
  5. Drosophila larval fat body surfaces : Changes in transplant compatibility during development. Rizki RM, et al. Wilehm Roux Arch Dev Biol, 1983 Jan. PMID 28305327

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucosidase 1
Names
CG1597-PB
CG1597-PC
GCS1-PB
GCS1-PC
NP_001245621.1
NP_572707.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11344506..11348001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132479.3 → NP_572707.4  glucosidase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572707.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R68, Q9VZ04
    Conserved Domains (2) summary
    pfam03200
    Location:352 → 847
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:104 → 283
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

  2. NM_001258692.2 → NP_001245621.1  glucosidase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R68, Q9VZ04
    Conserved Domains (2) summary
    pfam03200
    Location:352 → 847
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:104 → 283
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95R68 Q95R68
Q9VZ04 Q9VZ04

Gene LinkOut

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