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dsh - dishevelled

Enables phosphatidic acid binding activity; protein domain specific binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including morphogenesis of an epithelium; neuron differentiation; and positive regulation of cell projection organization. Located in apical cortex and plasma membrane. Part of Wnt signalosome. Is expressed in arista; dorsal-ventral compartment boundary of imaginal disc; egg chamber; imaginal disc; and organism. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in DiGeorge syndrome; autosomal dominant Robinow syndrome 2; autosomal dominant Robinow syndrome 3; and lung cancer. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to dsh

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Species Gene Architecture aa