Dcaf5 DDB1 and CUL4 associated factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf5provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 5provided by MGI
Primary source: MGI:MGI:2444785
See related: Ensembl:ENSMUSG00000049106 AllianceGenome:MGI:2444785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BCRG2; BCRP2; Wdr22; 9430020B07Rik
Summary: Predicted to be involved in negative regulation of fatty acid biosynthetic process. Located in mitochondrion. Orthologous to human DCAF5 (DDB1 and CUL4 associated factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 44.4), ovary adult (RPKM 13.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 36.61 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (80382622..80483375, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (80335848..80436601, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of L3MBTL3 or DCAF5 is sufficient to restore the protein levels of SOX2 and rescue the defects of mouse embryonic stem cells caused by LSD1 or PHF20L1 deficiency.
Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.
Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S848 (e-PCR)
- UniSTS:29576

RH140793 (e-PCR)
- UniSTS:222859

AI325023 (e-PCR)
- UniSTS:180414

AI848110 (e-PCR)
- UniSTS:180415

AW124614 (e-PCR)
- UniSTS:180416

AI430035 (e-PCR)
- UniSTS:160222

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 5

Names: WD repeat domain 22; WD repeat-containing protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364324.1 → NP_001351253.1 DDB1- and CUL4-associated factor 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC134594, AC163282, CT030161

Conserved Domains (2) summary

sd00039
Location:22 → 58

7WD40; WD40 repeat [structural motif]

cl25539
Location:13 → 317

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_177267.5 → NP_796241.3 DDB1- and CUL4-associated factor 5 isoform 1

See identical proteins and their annotated locations for NP_796241.3

Status: VALIDATED

Source sequence(s)

AK137579, CT030161

Consensus CDS

CCDS26013.1

UniProtKB/Swiss-Prot

Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6

UniProtKB/TrEMBL

Q3UV57

Related

ENSMUSP00000052755.7, ENSMUST00000054145.8

Conserved Domains (3) summary

COG2319
Location:16 → 361

WD40; WD40 repeat [General function prediction only]

sd00039
Location:57 → 98

7WD40; WD40 repeat [structural motif]

cl02567
Location:49 → 361

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...