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Gs2 Glutamine synthetase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32087, updated on 9-Dec-2024

Summary

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Official Symbol
Gs2provided by FlyBase
Official Full Name
Glutamine synthetase 2provided by FlyBase
Primary source
FLYBASE:FBgn0001145
Locus tag
Dmel_CG1743
See related
AllianceGenome:FB:FBgn0001145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1743; Dmel\CG1743; DmGS2; gs-c; gs2; GS2; GsII
Summary
Enables glutamine synthetase activity. Involved in glutamate catabolic process and synapse assembly. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; epithelium; ganglia; glial cell; and synaptic neuropil domain. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gs2 in Genome Data Viewer
Location:
10B11-10B11; 1-34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11422832..11430197)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11316865..11324230)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 10b Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Ecotropic viral integration site 5 Neighboring gene Sphingosine kinase 1 Neighboring gene Heterochromatin protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2. Chen WT, et al. Biomolecules, 2020 Dec 14. PMID 33327463, Free PMC Article
  2. A Distinct Perisynaptic Glial Cell Type Forms Tripartite Neuromuscular Synapses in the Drosophila Adult. Strauss AL, et al. PLoS One, 2015. PMID 26053860, Free PMC Article
  3. Homologous nuclear genes encode cytoplasmic and mitochondrial glutamine synthetase in Drosophila melanogaster. Caizzi R, et al. J Mol Biol, 1990 Mar 5. PMID 1969491
  4. Purification of the glutamine synthetase II isozyme of Drosophila melanogaster and structural and functional comparison of glutamine synthetases I and II. De Pinto V, et al. Biochem Genet, 1987 Dec. PMID 2897195
  5. Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling. Farca Luna AJ, et al. J Neurosci, 2017 Apr 19. PMID 28314820, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
    Title: Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutamine synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamine synthetase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine synthetase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutamate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutamine synthetase 2
Names
CG1743-PA
CG1743-PB
CG1743-PC
CG1743-PD
CG1743-PE
CG1743-PF
Glutamate-ammonia ligase
Gs2-PA
Gs2-PB
Gs2-PC
Gs2-PD
Gs2-PE
Gs2-PF
cytoplasmic glutamine synthetase
glutamine synthase 2
glutamine synthetase
NP_001285121.1
NP_001285122.1
NP_001285123.1
NP_511123.2
NP_727525.1
NP_996408.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11422832..11430197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298192.1 → NP_001285121.1  glutamine synthetase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285121.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV58, X2JDA5
    Conserved Domains (1) summary
    PLN02284
    Location:27 → 372
    PLN02284; glutamine synthetase

  2. NM_167284.2 → NP_727525.1  glutamine synthetase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV58, Q494K4
    Related
    FBpp0073344
    Conserved Domains (1) summary
    PLN02284
    Location:23 → 368
    PLN02284; glutamine synthetase

  3. NM_001298194.1 → NP_001285123.1  glutamine synthetase 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20478, Q8IR90, Q95SM4, Q9VYZ0
    UniProtKB/TrEMBL
    C8VV58, X2JJG8
    Conserved Domains (1) summary
    PLN02284
    Location:23 → 368
    PLN02284; glutamine synthetase

  4. NM_001298193.1 → NP_001285122.1  glutamine synthetase 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285122.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20478, Q8IR90, Q95SM4, Q9VYZ0
    UniProtKB/TrEMBL
    C8VV58, X2JJG8
    Conserved Domains (1) summary
    PLN02284
    Location:23 → 368
    PLN02284; glutamine synthetase

  5. NM_206685.2 → NP_996408.1  glutamine synthetase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996408.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20478
    Conserved Domains (1) summary
    pfam00120
    Location:28 → 259
    Gln-synt_C; Glutamine synthetase, catalytic domain

  6. NM_078568.3 → NP_511123.2  glutamine synthetase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511123.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20478, Q8IR90, Q95SM4, Q9VYZ0
    UniProtKB/TrEMBL
    C8VV58, X2JJG8
    Related
    FBpp0073345
    Conserved Domains (1) summary
    PLN02284
    Location:23 → 368
    PLN02284; glutamine synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20478.3 P20478
X2JDA5 X2JDA5
X2JJG8 X2JJG8

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