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bif bifocal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32119, updated on 9-Dec-2024

Summary

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Official Symbol
bifprovided by FlyBase
Official Full Name
bifocalprovided by FlyBase
Primary source
FLYBASE:FBgn0014133
Locus tag
Dmel_CG1822
See related
AllianceGenome:FB:FBgn0014133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bif; bif CES; CG1822; Dmel\CG1822
Summary
Enables actin filament binding activity and microtubule binding activity. Involved in axon guidance and negative regulation of axon extension. Located in cytoplasm. Is expressed in several structures, including adult head; eye disc posterior to the morphogenetic furrow; eye photoreceptor cell; furrow canal; and tract. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See bif in Genome Data Viewer
Location:
10D4-10D5; 1-35 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11678970..11694740)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11573003..11588773)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 10D Neighboring gene Valette Neighboring gene Phosphorylase kinase gamma Neighboring gene uncharacterized protein Neighboring gene alpha1,6-fucosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye. Helps NR, et al. Mol Cell Biol, 2001 Mar. PMID 11238949, Free PMC Article
  2. Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body. Kurusu M, et al. Mol Cell Neurosci, 2008 May. PMID 18356078, Free PMC Article
  3. Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes. Babu K, et al. Genes Dev, 2004 Jan 15. PMID 14752008, Free PMC Article
  4. The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis. Bahri SM, et al. Mol Cell Biol, 1997 Sep. PMID 9271427, Free PMC Article
  5. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Kaye EG, et al. Mol Cell Biol, 2017 Nov 1. PMID 28784719, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bif regulates PP1 activity, and both proteins influence cytoskeleton dynamics in the growth cone of R cells to allow proper axon targeting.
    Title: Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila.
  2. Data suggest that Bifocal functions downstream of Misshapen to reorganize actin cytoskeleton in decelerating R cell growth cone motility at the target region.
    Title: Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuronal signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in rough endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifocal
Names
CG1822-PB
CG1822-PC
CG1822-PD
CG1822-PE
CG1822-PF
bif-PB
bif-PC
bif-PD
bif-PE
bif-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11678970..11694740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272527.2 → NP_001259456.1  bifocal, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259456.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHL6, O16125

  2. NM_001272528.2 → NP_001259457.1  bifocal, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHA0, O16125

  3. NM_078573.4 → NP_511128.2  bifocal, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511128.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16125, Q9VYV8
    Related
    FBpp0073372

  4. NM_167295.3 → NP_727547.1  bifocal, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR86, Q962F2
    Related
    FBpp0073371

  5. NM_001272526.2 → NP_001259455.1  bifocal, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259455.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGW8, Q962F2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGW8 M9PGW8
M9PHA0 M9PHA0
M9PHL6 M9PHL6
O16125 O16125
Q8IR86 Q8IR86
Q962F2 Q962F2
Q9VYV8 Q9VYV8

Gene LinkOut

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