dy dusky [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dyprovided by FlyBase
Official Full Name: duskyprovided by FlyBase
Primary source: FLYBASE:FBgn0004511
Locus tag: Dmel_CG9355
See related: AllianceGenome:FB:FBgn0004511
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ala; CG9355; Dmel\CG9355; dy1
Summary: Involved in cell morphogenesis and imaginal disc-derived wing morphogenesis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in adult head and wing disc. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11769769..11778784, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11663802..11672817, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

dyl is essential for the maintenance of hair integrity.
Title: dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing.
Dusky encodes transmembrane proteins containing a ZP (zona pellucida) domain and is homologous to several vertebrate and invertebrate apical matrix components. Dusky is only expressed in tissues secreting a cuticle.
Title: Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis.
functions as structural component of the Drosophila cuticulin layer
Title: Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin.

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Process	Evidence Code	Pubs
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain