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rudhira rudhira [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32136, updated on 9-Dec-2024

Summary

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Official Symbol
rudhiraprovided by FlyBase
Official Full Name
rudhiraprovided by FlyBase
Primary source
FLYBASE:FBgn0266019
Locus tag
Dmel_CG43154
See related
AllianceGenome:FB:FBgn0266019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-2.41; CG1905; CG32662; CG32663; CG43154; clone 2.41; Dmel\CG43154; Drudh; DRudh; Rudh
Old locus tag
Dmel_CG32662; Dmel_CG32663
Summary
Involved in macropinocytosis. Located in cytoplasm. Is expressed in adult brain; adult head; adult pericardial cell; embryonic/larval garland cell; and larval pericardial cell. Used to study Hengel-Maroofian-Schols syndrome. Human ortholog(s) of this gene implicated in Hengel-Maroofian-Schols syndrome. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See rudhira in Genome Data Viewer
Location:
10E6-10F1; 1-36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11816898..11837460)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11710931..11731493)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43908 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 28c1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder. Hengel H, et al. Am J Hum Genet, 2021 Jun 3. PMID 34022130, Free PMC Article
  2. Macromolecular uptake in Drosophila pericardial cells requires rudhira function. Das D, et al. Exp Cell Res, 2008 May 1. PMID 18355807
  3. Gene expression analysis in post-embryonic pericardial cells of Drosophila. Das D, et al. Gene Expr Patterns, 2008 Feb. PMID 18060846
  4. Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier. Müller M, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32510132, Free PMC Article
  5. Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation. Cui J, et al. Genetics, 2008 Apr. PMID 18430932, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
rudhira
Names
CG43154-PB
CG43154-PC
CG43154-PD
CG43154-PE
CG43154-PF
CG43154-PG
rudhira-PB
rudhira-PC
rudhira-PD
rudhira-PE
rudhira-PF
rudhira-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11816898..11837460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258702.1 → NP_001245631.1  rudhira, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SY41
    UniProtKB/TrEMBL
    M9NED8
    Conserved Domains (1) summary
    pfam12490
    Location:635 → 822
    BCAS3; Breast carcinoma amplified sequence 3

  2. NM_167309.3 → NP_727567.1  rudhira, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SY41
    UniProtKB/TrEMBL
    M9NED8
    Conserved Domains (1) summary
    pfam12490
    Location:635 → 822
    BCAS3; Breast carcinoma amplified sequence 3

  3. NM_001382106.1 → NP_001368979.1  rudhira, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EFK5
    Conserved Domains (1) summary
    pfam12490
    Location:648 → 818
    BCAS3; Breast carcinoma amplified sequence 3

  4. NM_001258703.2 → NP_001245632.1  rudhira, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYU0
    Conserved Domains (1) summary
    pfam12490
    Location:635 → 822
    BCAS3; Breast carcinoma amplified sequence 3

  5. NM_132522.3 → NP_572750.3  rudhira, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572750.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYU0
    Conserved Domains (1) summary
    pfam12490
    Location:635 → 822
    BCAS3; Breast carcinoma amplified sequence 3

  6. NM_001272534.1 → NP_001259463.1  rudhira, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259463.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SY41
    UniProtKB/TrEMBL
    M9NED8
    Conserved Domains (1) summary
    pfam12490
    Location:635 → 822
    BCAS3; Breast carcinoma amplified sequence 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6H2EFK5 A0A6H2EFK5
M9NED8 M9NED8
Q8SY41.1 Q8SY41
Q960P3 Q960P3
Q9VYU0 Q9VYU0

Gene LinkOut

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