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CG1847 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32144, updated on 4-Jan-2025

Summary

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Official Symbol
CG1847provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030345
Locus tag
Dmel_CG1847
See related
AllianceGenome:FB:FBgn0030345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1847
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein maturation by protein folding and protein targeting to mitochondrion. Predicted to be located in cytosol. Is expressed in embryonic/larval crystal cell; organism; and procrystal cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; pituitary adenoma 1; and retinitis pigmentosa. Orthologous to several human genes including AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG1847 in Genome Data Viewer
Location:
10F2-10F2; 1-37 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11869170..11871168)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11763203..11765201)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATP7 Neighboring gene Nardilysin Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo bioassay to test the pathogenicity of missense human AIP variants. Aflorei ED, et al. J Med Genet, 2018 Aug. PMID 29632148, Free PMC Article
  2. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. Ghartey-Kwansah G, et al. BMC Dev Biol, 2018 Mar 27. PMID 29587629, Free PMC Article
  3. shutdown is a component of the Drosophila piRNA biogenesis machinery. Preall JB, et al. RNA, 2012 Aug. PMID 22753781, Free PMC Article
  4. Cumulative contributions of weak DNA determinants to targeting the Drosophila dosage compensation complex. Gilfillan GD, et al. Nucleic Acids Res, 2007. PMID 17483514, Free PMC Article
  5. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein maturation by protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1847-PA
CG1847-PC
CG1847-PD
NP_001368980.1
NP_572758.1
NP_727574.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11869170..11871168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382046.1 → NP_001368980.1  uncharacterized protein Dmel_CG1847, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EG45
    Conserved Domains (3) summary
    TIGR00990
    Location:150 → 308
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:173 → 217
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:23 → 92
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_132530.4 → NP_572758.1  uncharacterized protein Dmel_CG1847, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYT2
    Related
    FBpp0073411
    Conserved Domains (3) summary
    sd00006
    Location:173 → 217
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:23 → 92
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:173 → 254
    TPR_11; TPR repeat

  3. NM_167311.3 → NP_727574.2  uncharacterized protein Dmel_CG1847, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727574.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR85
    Conserved Domains (3) summary
    sd00006
    Location:173 → 217
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:23 → 92
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:173 → 254
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6H2EG45 A0A6H2EG45
Q8IR85 Q8IR85
Q8SX17 Q8SX17
Q9VYT2 Q9VYT2

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