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sicily severe impairment of CI with lengthened youth [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32151, updated on 4-Jan-2025

Summary

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Official Symbol
sicilyprovided by FlyBase
Official Full Name
severe impairment of CI with lengthened youthprovided by FlyBase
Primary source
FLYBASE:FBgn0030352
Locus tag
Dmel_CG15738
See related
AllianceGenome:FB:FBgn0030352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15738; Dmel\CG15738; dNDUFAF6; Sicily; XE07
Summary
Involved in protein stabilization. Located in mitochondrion. Is expressed in adult head and organism. Used to study Leigh disease and retinal degeneration. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 5 and nuclear type mitochondrial complex I deficiency 17. Orthologous to human NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sicily in Genome Data Viewer
Location:
10F4-10F4; 1-37 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11891732..11893745)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11785765..11787778)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Selenoprotein G Neighboring gene uncharacterized protein Neighboring gene wispy Neighboring gene Upf1 RNA helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them. Maruko A, et al. iScience, 2023 Nov 17. PMID 37915609, Free PMC Article
  2. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Tsai PI, et al. Mol Cell, 2018 Mar 1. PMID 29456190
  3. The X-linked 1.688 Satellite in Drosophila melanogaster Promotes Specific Targeting by Painting of Fourth. Kim M, et al. Genetics, 2018 Feb. PMID 29242291, Free PMC Article
  4. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. Zhang K, et al. J Cell Biol, 2013 Mar 18. PMID 23509070, Free PMC Article
  5. Genetic strategies to tackle neurological diseases in fruit flies. Şentürk M, et al. Curr Opin Neurobiol, 2018 Jun. PMID 29128849, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
severe impairment of CI with lengthened youth
Names
CG15738-PA
CG15738-PB
sicily-PA
sicily-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11891732..11893745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298213.1 → NP_001285142.1  severe impairment of CI with lengthened youth, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYS5
    UniProtKB/TrEMBL
    X2JJK8
    Conserved Domains (1) summary
    pfam00494
    Location:60 → 312
    SQS_PSY; Squalene/phytoene synthase

  2. NM_132537.2 → NP_572765.1  severe impairment of CI with lengthened youth, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572765.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYS5
    UniProtKB/TrEMBL
    X2JJK8
    Related
    FBpp0073416
    Conserved Domains (1) summary
    pfam00494
    Location:60 → 312
    SQS_PSY; Squalene/phytoene synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYS5.1 Q9VYS5
X2JJK8 X2JJK8

Gene LinkOut

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