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CG1492 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32164, updated on 9-Dec-2024

Summary

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Official Symbol
CG1492provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030361
Locus tag
Dmel_CG1492
See related
AllianceGenome:FB:FBgn0030361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1492
Summary
Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1); GGT2P (gamma-glutamyltransferase 2, pseudogene); and GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG1492 in Genome Data Viewer
Location:
11A1-11A1; 1-38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12009711..12012211, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11904033..11906244, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene furrowed Neighboring gene uncharacterized protein Neighboring gene regucalcin Neighboring gene Chromatin accessibility complex 16kD protein Neighboring gene LSM12 homolog a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
  2. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article
  3. Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes. Demakova OV, et al. Chromosoma, 2020 Mar. PMID 31820086
  4. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
  5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1492-PA
CG1492-PB
NP_001303553.1
NP_572774.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12009711..12012211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316624.1 → NP_001303553.1  uncharacterized protein Dmel_CG1492, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZ81, Q9VYR2
    Conserved Domains (1) summary
    pfam01019
    Location:76 → 587
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_132546.3 → NP_572774.1  uncharacterized protein Dmel_CG1492, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZ81, Q9VYR2
    Related
    FBpp0073423
    Conserved Domains (1) summary
    pfam01019
    Location:76 → 587
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYR2 Q9VYR2

Gene LinkOut

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