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Uch-L5R Uch-L5-related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32173, updated on 9-Dec-2024

Summary

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Official Symbol
Uch-L5Rprovided by FlyBase
Official Full Name
Uch-L5-relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0030370
Locus tag
Dmel_CG1950
See related
AllianceGenome:FB:FBgn0030370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1950; Dmel\CG1950; dUCHL5R; Uch37R; UCHL5R
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle. Predicted to be active in cytoplasm. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Uch-L5R in Genome Data Viewer
Location:
11A2-11A2; 1-38 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12055338..12056635, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11949371..11950668, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43960 Neighboring gene Cytochrome P450 311a1 Neighboring gene Cytochrome P450 318a1 Neighboring gene long non-coding RNA:CR43961 Neighboring gene Tenascin accessory Neighboring gene Mucin 11A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease. Tran HH, et al. Sci Rep, 2018 Mar 13. PMID 29535397, Free PMC Article
  2. The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. Zhou Z, et al. J Mol Cell Biol, 2018 Jun 1. PMID 28992318
  3. RNA-Sequencing of Drosophila melanogaster Head Tissue on High-Sugar and High-Fat Diets. Hemphill W, et al. G3 (Bethesda), 2018 Jan 4. PMID 29141990, Free PMC Article
  4. Systematic analysis of the physiological importance of deubiquitinating enzymes. Tsou WL, et al. PLoS One, 2012. PMID 22937016, Free PMC Article
  5. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Uch-L5-related
Names
CG1950-PA
Uch-L5R-PA
NP_572781.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12055338..12056635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132553.1 → NP_572781.1  Uch-L5-related [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B4F522, B4F523, C0ML09, C0ML11, Q9VYQ3
    Related
    FBpp0073471, FBtr0073638
    Conserved Domains (1) summary
    cd09617
    Location:25 → 238
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T487 Q8T487
Q9VYQ3 Q9VYQ3

Gene LinkOut

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