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ube2d3 ubiquitin-conjugating enzyme E2D 3 [ Danio rerio (zebrafish) ]

Gene ID: 321832, updated on 9-Dec-2024

Summary

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Official Symbol
ube2d3provided by ZNC
Official Full Name
ubiquitin-conjugating enzyme E2D 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-551
See related
Ensembl:ENSDARG00000038473 AllianceGenome:ZFIN:ZDB-GENE-030131-551
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eff; fb36f02; zgc:56340; wu:fb36f02
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in myotome. Orthologous to human UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ube2d3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (11746244..11763191, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (11613767..11630872, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 8 Neighboring gene mannosidase, beta A, lysosomal Neighboring gene zmp:0000000662 Neighboring gene uncharacterized LOC108191961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Specific inhibition of splicing factor activity by decoy RNA oligonucleotides. Denichenko P, et al. Nat Commun, 2019 Apr 8. PMID 30962446, Free PMC Article
  2. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 D3
Names
ubiquitin-conjugating enzyme E2D 2
NP_955865.1
XP_005156599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199571.1 → NP_955865.1  ubiquitin-conjugating enzyme E2 D3

    See identical proteins and their annotated locations for NP_955865.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047863
    UniProtKB/TrEMBL
    A0A8M1PFH3, Q7ZUR2
    Related
    ENSDARP00000150757.1, ENSDART00000187819.1
    Conserved Domains (1) summary
    cl00154
    Location:1 → 146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    11746244..11763191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156542.5 → XP_005156599.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

    See identical proteins and their annotated locations for XP_005156599.1

    UniProtKB/TrEMBL
    A0A8M2B3F7, A9JRT4
    Related
    ENSDARP00000093157.5, ENSDART00000102381.6
    Conserved Domains (1) summary
    cl00154
    Location:1 → 146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version

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