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cyth1a cytohesin 1a [ Danio rerio (zebrafish) ]

Gene ID: 321938, updated on 4-Jan-2025

Summary

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Official Symbol
cyth1aprovided by ZNC
Official Full Name
cytohesin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-657
See related
Ensembl:ENSDARG00000076742 AllianceGenome:ZFIN:ZDB-GENE-030131-657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cyth1; pscd1; fb38g09; wu:fb38g09; zgc:152822
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second. Is expressed in blastoderm. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cyth1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (57462223..57578496, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (57391699..57508007, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 235-like Neighboring gene suppressor of cytokine signaling 3a Neighboring gene ubiquitin specific peptidase 36 Neighboring gene uncharacterized LOC101883359 Neighboring gene TIMP metallopeptidase inhibitor 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress. West JJ, et al. Curr Biol, 2017 Aug 7. PMID 28736167
  2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  3. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
  4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC152822

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytohesin-1a
Names
cytohesin 1
pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214682.2 → NP_999847.1  cytohesin-1a

    See identical proteins and their annotated locations for NP_999847.1

    Status: VALIDATED

    Source sequence(s)
    CR792428
    UniProtKB/TrEMBL
    A0A8M1PQL7, A0A8M6Z3G1, Q6PW01
    Related
    ENSDARP00000006121.7, ENSDART00000003066.9
    Conserved Domains (4) summary
    cd01252
    Location:261 → 379
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:265 → 377
    PH; PH domain
    pfam01369
    Location:64 → 246
    Sec7; Sec7 domain
    pfam17075
    Location:10 → 83
    RRT14; Regular of rDNA transcription protein 14

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    57462223..57578496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215811.1 → XP_068071912.1  cytohesin-1a isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z3G1

  2. XM_017353253.3 → XP_017208742.1  cytohesin-1a isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z3G1, A0A8M6Z459

  3. XM_017353258.3 → XP_017208747.2  cytohesin-1a isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z1X0
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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