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mfsd14a2 major facilitator superfamily domain containing 14A2 [ Danio rerio (zebrafish) ]

Gene ID: 322115, updated on 4-Jan-2025

Summary

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Official Symbol
mfsd14a2provided by ZNC
Official Full Name
major facilitator superfamily domain containing 14A2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-834
See related
Ensembl:ENSDARG00000013117 AllianceGenome:ZFIN:ZDB-GENE-030131-834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hiat1a; zgc:63758; wu:fb50e05
Summary
Predicted to enable transmembrane transporter activity. Acts upstream of or within ammonium excretion. Predicted to be located in membrane. Is expressed in several structures, including digestive system; hatching gland; heart; nervous system; and solid lens vesicle. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mfsd14a2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37656078..37684585, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37673621..37702128, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18a Neighboring gene insulin receptor a Neighboring gene myosin IXb Neighboring gene myeloid associated differentiation marker b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of two novel ammonia transporters, Hiat1a and Hiat1b, in the teleost model system Danio rerio. Zhouyao H, et al. J Exp Biol, 2022 Oct 15. PMID 36124551
  2. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
  3. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ammonium excretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MFSD14 family MFS transporter
Names
hippocampus abundant transcript 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199584.1 → NP_955878.1  MFSD14 family MFS transporter

    See identical proteins and their annotated locations for NP_955878.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056817
    UniProtKB/TrEMBL
    Q6PGV6
    Related
    ENSDARP00000027246.6, ENSDART00000012191.7
    Conserved Domains (2) summary
    cd06174
    Location:40 → 393
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:42 → 386
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37656078..37684585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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