cct5 chaperonin containing TCP1, subunit 5 (epsilon) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cct5provided by ZNC
Official Full Name: chaperonin containing TCP1, subunit 5 (epsilon)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-977
See related: Ensembl:ENSDARG00000045399 AllianceGenome:ZFIN:ZDB-GENE-030131-977
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: unm_tf212; wu:fb54h08
Summary: Predicted to enable unfolded protein binding activity. Acts upstream of or within retina layer formation and skeletal muscle thin filament assembly. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including epidermis; nervous system; pharyngeal arch 3-7 skeleton; proliferative region; and yolk syncytial layer. Orthologous to human CCT5 (chaperonin containing TCP1 subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (16905218..16912894)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (16760799..16768475)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa28h05.s1 (e-PCR)
- UniSTS:189606

AI477038 (e-PCR)
- UniSTS:206533

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle thin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: T-complex protein 1 subunit epsilon

Names: TCP-1 epsilon; unm tf212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212613.1 → NP_997778.1 T-complex protein 1 subunit epsilon

See identical proteins and their annotated locations for NP_997778.1

Status: PROVISIONAL

Source sequence(s)

AY398321

UniProtKB/TrEMBL

Q6DRF2, Q6NVI6

Related

ENSDARP00000066759.3, ENSDART00000066760.4

Conserved Domains (2) summary

cd03339
Location:10 → 535

TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

pfam00118
Location:44 → 533

Cpn60_TCP1; TCP-1/cpn60 chaperonin family