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Paics - PAICS bifunctional enzyme

Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; epithelium; female germline cell; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa