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GstT4 Glutathione S transferase T4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32299, updated on 9-Dec-2024

Summary

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Official Symbol
GstT4provided by FlyBase
Official Full Name
Glutathione S transferase T4provided by FlyBase
Primary source
FLYBASE:FBgn0030484
Locus tag
Dmel_CG1681
See related
AllianceGenome:FB:FBgn0030484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1681; dGSTT4; Dmel\CG1681; DmGSTT4; GST-theta; gstt4; GSTT4
Summary
Predicted to enable glutathione peroxidase activity. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See GstT4 in Genome Data Viewer
Location:
11F4-11F4; 1-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13404749..13409323)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13298782..13303356)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Branched chain amino acid transaminase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification. Kuzin BA, et al. PLoS One, 2014. PMID 24736732, Free PMC Article
  2. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
  3. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. Kilwein MD, et al. PLoS Genet, 2023 Aug. PMID 37578970, Free PMC Article
  4. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
  5. Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers. Akishina AA, et al. Oncotarget, 2017 Nov 28. PMID 29262535, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase T4
Names
CG1681-PA
GstT4-PA
NP_572886.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13404749..13409323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132658.2 → NP_572886.2  glutathione S transferase T4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572886.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F6J6F4, Q8MRM0, Q9VYD3
    Related
    FBpp0073609
    Conserved Domains (2) summary
    cd03183
    Location:95 → 220
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:5 → 80
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRM0 Q8MRM0

Gene LinkOut

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