CG12177 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG12177provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0030510
Locus tag: Dmel_CG12177
See related: AllianceGenome:FB:FBgn0030510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG12177
Summary: Predicted to enable ribosylpyrimidine nucleosidase activity. Predicted to be involved in pyrimidine nucleoside catabolic process. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; ganglia; gut section; and head mesoderm. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 12B2-12B2; 1-45 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13677899..13680500, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13571932..13574533, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables ribosylpyrimidine nucleosidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in pyrimidine nucleoside catabolic process	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG12177-PA; CG12177-PB; CG12177-PC

NP_001285222.1

EC 3.2.2.-

EC 3.2.2.8

NP_001285223.1

EC 3.2.2.-

EC 3.2.2.8

NP_572911.1

EC 3.2.2.-

EC 3.2.2.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13677899..13680500 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132683.2 → NP_572911.1 uncharacterized protein Dmel_CG12177, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572911.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYA1

Related

FBpp0073677

Conserved Domains (1) summary

cd02649
Location:25 → 347

nuc_hydro_CeIAG; nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. ...
NM_001298294.1 → NP_001285223.1 uncharacterized protein Dmel_CG12177, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285223.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYA1

Conserved Domains (1) summary

cd02649
Location:25 → 347

nuc_hydro_CeIAG; nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. ...
NM_001298293.1 → NP_001285222.1 uncharacterized protein Dmel_CG12177, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285222.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYA1

Conserved Domains (1) summary

cd02649
Location:25 → 347

nuc_hydro_CeIAG; nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. ...