CtsB Cathepsin B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CtsBprovided by FlyBase
Official Full Name: Cathepsin Bprovided by FlyBase
Primary source: FLYBASE:FBgn0030521
Locus tag: Dmel_CG10992
See related: AllianceGenome:FB:FBgn0030521
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:ParkEST132; CathB; CB; CG-10992; CG10992; CTSB; Ctsb1; CtsB1; CTSB1; Dmel\CG10992
Summary: Enables cysteine-type endopeptidase activity. Involved in proteolysis. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; apoptotic amnioserosa; and ganglia. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12C4-12C4; 1-46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13779847..13782170, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13673880..13676203, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alanine substitution of residues W9, Y12, F16, Y20, Y32, and W53 within the hydrophobic cores, and charged residues E8, R28, R29, and E67 in the salt bridges considerably decrease the ability of crammer to inhibit cathepsin B (CTSB).
Title: Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of catalytic activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in perivitelline space	HDA more info	PubMed

General protein information

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Preferred Names: cathepsin B

Names: CG10992-PA; CG10992-PC; CtsB-PA; CtsB-PC; cathepsin B1

NP_001259536.2

EC 3.4.-.-

EC 3.4.22.-

NP_572920.1

EC 3.4.-.-

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13779847..13782170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272607.2 → NP_001259536.2 cathepsin B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259536.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PH35, Q9VY87

Conserved Domains (2) summary

cd02620
Location:88 → 336

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:24 → 64

Propeptide_C1; Peptidase family C1 propeptide
NM_132692.3 → NP_572920.1 cathepsin B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572920.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH35, Q9VY87

Related

FBpp0073669

Conserved Domains (2) summary

cd02620
Location:88 → 336

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:24 → 64

Propeptide_C1; Peptidase family C1 propeptide