U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

amrt amaretto [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32342, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
amrtprovided by FlyBase
Official Full Name
amarettoprovided by FlyBase
Primary source
FLYBASE:FBgn0030522
Locus tag
Dmel_CG11103
See related
AllianceGenome:FB:FBgn0030522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LP03404; CG11103; Dmel\CG11103
Summary
Involved in positive regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in organism. Used to study Alzheimer's disease. Orthologous to human TM2D2 (TM2 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See amrt in Genome Data Viewer
Location:
12C4-12C4; 1-46 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13782459..13783381)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13676492..13677414)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene retinal degeneration B Neighboring gene Cathepsin B Neighboring gene inactivation no afterpotential E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional unknomics: Systematic screening of conserved genes of unknown function. Rocha JJ, et al. PLoS Biol, 2023 Aug. PMID 37552676, Free PMC Article
  2. TM2D genes regulate Notch signaling and neuronal function in Drosophila. Salazar JL, et al. PLoS Genet, 2021 Dec. PMID 34905536, Free PMC Article
  3. Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits. Godfrey RK, et al. Acta Neuropathol Commun, 2023 Oct 20. PMID 37864255, Free PMC Article
  4. Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster. Megaly M, et al. Front Biosci (Landmark Ed), 2024 Jun 25. PMID 38940046
  5. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TM2D genes regulate Notch signaling and neuronal function in Drosophila.
    Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
amaretto
Names
CG11103-PC
amrt-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13782459..13783381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038753.2 → NP_001033842.2  amaretto [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VY86
    Conserved Domains (1) summary
    pfam05154
    Location:156 → 205
    TM2; TM2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY86.3 Q9VY86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools