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nmdyn-D6 nmdyn-D6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32396, updated on 9-Dec-2024

Summary

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Official Symbol
nmdyn-D6provided by FlyBase
Official Full Name
nmdyn-D6provided by FlyBase
Primary source
FLYBASE:FBgn0030573
Locus tag
Dmel_CG5310
See related
AllianceGenome:FB:FBgn0030573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5310; Dmel\CG5310
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in cilium movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and nucleoside triphosphate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in cilium. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See nmdyn-D6 in Genome Data Viewer
Location:
12F1-12F1; 1-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14583677..14584616)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14477710..14478649)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45521 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene sobremesa Neighboring gene Netrin-A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. Bernstein AI, et al. Hum Mol Genet, 2016 Jun 15. PMID 27060332, Free PMC Article
  2. Fat body-specific reduction of CTPS alleviates HFD-induced obesity. Liu J, et al. Elife, 2023 Sep 11. PMID 37695169, Free PMC Article
  3. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Cayirlioglu P, et al. Mol Cell Biol, 2003 Mar. PMID 12612083, Free PMC Article
  4. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article
  5. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside triphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nmdyn-D6
Names
CG5310-PA
nmdyn-D6-PA
NP_572965.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14583677..14584616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132737.2 → NP_572965.1  nmdyn-D6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572965.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QG0, Q9N6S7, Q9VY27
    Related
    FBpp0073750
    Conserved Domains (2) summary
    smart00562
    Location:2 → 138
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04414
    Location:2 → 135
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY27 Q9VY27

Gene LinkOut

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