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sbm sobremesa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32397, updated on 9-Dec-2024

Summary

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Official Symbol
sbmprovided by FlyBase
Official Full Name
sobremesaprovided by FlyBase
Primary source
FLYBASE:FBgn0030574
Locus tag
Dmel_CG9413
See related
AllianceGenome:FB:FBgn0030574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9413; Dmel\CG9413; Sbm
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Located in cell cortex. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sbm in Genome Data Viewer
Location:
12F1-12F1; 1-49 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14584733..14602580, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14478766..14496613, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nmdyn-D6 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene Netrin-A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
  2. Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties. Reynolds B, et al. Biochem J, 2009 May 27. PMID 19335336, Free PMC Article
  3. Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. Augustin H, et al. J Neurosci, 2007 Jan 3. PMID 17202478, Free PMC Article
  4. Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Galagovsky D, et al. Cell Rep, 2018 Sep 18. PMID 30231999, Free PMC Article
  5. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sbm modulates brain development and the timing of larval development via an amino-acid-sensitive and Dilp-independent function of glia.
    Title: Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sobremesa
Names
CG9413-PA
CG9413-PB
CG9413-PC
CG9413-PD
sbm-PA
sbm-PB
sbm-PC
sbm-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14584733..14602580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298313.1 → NP_001285242.1  sobremesa, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BIK9, X2JK78
    Conserved Domains (1) summary
    TIGR00911
    Location:44 → 402
    2A0308; L-type amino acid transporter

  2. NM_132738.2 → NP_572966.1  sobremesa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572966.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC3, Q9VY26
    Related
    FBpp0073760
    Conserved Domains (1) summary
    TIGR00911
    Location:44 → 523
    2A0308; L-type amino acid transporter

  3. NM_001298312.1 → NP_001285241.1  sobremesa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285241.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC3, X2JDR1
    Conserved Domains (1) summary
    TIGR00911
    Location:53 → 512
    2A0308; L-type amino acid transporter

  4. NM_167411.3 → NP_727785.1  sobremesa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC3, Q8IR48
    Related
    FBpp0073761
    Conserved Domains (1) summary
    TIGR00911
    Location:53 → 532
    2A0308; L-type amino acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BIK9 Q5BIK9
Q8IR48 Q8IR48
Q9VY26 Q9VY26
X2JDR1 X2JDR1
X2JK78 X2JK78

Gene LinkOut

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