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CG5321 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32399, updated on 9-Dec-2024

Summary

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Official Symbol
CG5321provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030575
Locus tag
Dmel_CG5321
See related
AllianceGenome:FB:FBgn0030575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey66; Dmel\CG5321; gamma-BBH
Summary
Predicted to enable gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5321 in Genome Data Viewer
Location:
12F2-12F2; 1-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14679568..14681418)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14573601..14575451)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene sobremesa Neighboring gene Netrin-A Neighboring gene Netrin-B Neighboring gene uncharacterized protein Neighboring gene hog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Netrins guide Drosophila commissural axons at short range. Brankatschk M, et al. Nat Neurosci, 2006 Feb. PMID 16429137
  2. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
  3. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Musselman LP, et al. Dis Model Mech, 2011 Nov. PMID 21719444, Free PMC Article
  4. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article
  5. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-butyrobetaine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5321-PB
CG5321-PC
gamma-ButyroBetaine hydroxylase
NP_001285244.1
NP_572967.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14679568..14681418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132739.3 → NP_572967.2  uncharacterized protein Dmel_CG5321, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572967.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4S5, Q9VY24
    Conserved Domains (3) summary
    cd00250
    Location:127 → 395
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    TIGR02409
    Location:49 → 405
    carnitine_bodg; gamma-butyrobetaine hydroxylase
    cl01414
    Location:48 → 113
    DUF971; Protein of unknown function (DUF971)

  2. NM_001298315.1 → NP_001285244.1  uncharacterized protein Dmel_CG5321, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4S5, Q9VY24
    Conserved Domains (3) summary
    cd00250
    Location:127 → 395
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    TIGR02409
    Location:49 → 405
    carnitine_bodg; gamma-butyrobetaine hydroxylase
    cl01414
    Location:48 → 113
    DUF971; Protein of unknown function (DUF971)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY24 Q9VY24

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