U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tpm4b tropomyosin 4b [ Danio rerio (zebrafish) ]

Gene ID: 324244, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
tpm4bprovided by ZNC
Official Full Name
tropomyosin 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2964
See related
Ensembl:ENSDARG00000019128 AllianceGenome:ZFIN:ZDB-GENE-030131-2964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tmp4; zgc:63734; wu:fc22f09
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Predicted to be active in actin filament. Is expressed in cardiovascular system; cephalic musculature; epiphysis; and otic vesicle. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tpm4b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (55300425..55335891, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (55567558..55603036, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 3 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene uncharacterized LOC137488274 Neighboring gene lipoprotein lipase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Dube DK, et al. Cytoskeleton (Hoboken), 2017 Mar. PMID 27998020, Free PMC Article
  2. CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Hofeichner J, et al. Sci Rep, 2023 Dec 19. PMID 38114601, Free PMC Article
  3. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Tsedeke AT, et al. Dev Biol, 2021 Aug. PMID 33857482
  4. foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Whitesell TR, et al. Dev Biol, 2019 Sep 1. PMID 31199900
  5. The evolution of compositionally and functionally distinct actin filaments. Gunning PW, et al. J Cell Sci, 2015 Jun 1. PMID 25788699

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tropomyosin 4b
Names
TPM4-2 alpha
tropomyosin 4-2alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199675.2 → NP_955969.1  tropomyosin 4b

    See identical proteins and their annotated locations for NP_955969.1

    Status: VALIDATED

    Source sequence(s)
    AI444323, CU693474, CU693492
    UniProtKB/TrEMBL
    A0A8M1PFN8, Q7SXW1
    Related
    ENSDARP00000137812.1, ENSDART00000169382.2
    Conserved Domains (1) summary
    pfam00261
    Location:13 → 246
    Tropomyosin; Tropomyosin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    55300425..55335891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357672.3 → XP_017213161.1  tropomyosin 4b isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z082

  2. XM_017357674.3 → XP_017213163.1  tropomyosin 4b isoform X1

    UniProtKB/TrEMBL
    A0A1L6UW65
    Related
    ENSDARP00000143569.2, ENSDART00000177924.2
    Conserved Domains (2) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin
    pfam16526
    Location:13 → 72
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous