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Top1 Topoisomerase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32458, updated on 9-Dec-2024

Summary

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Official Symbol
Top1provided by FlyBase
Official Full Name
Topoisomerase 1provided by FlyBase
Primary source
FLYBASE:FBgn0004924
Locus tag
Dmel_CG6146
See related
AllianceGenome:FB:FBgn0004924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6146; Dmel\CG6146; dTopoI; l(1)G0134; l(1)G0201; l(1)G0229; l(1)G0278; l(1)top1; ND432; top1; TOP1; TopI; topo I; Topo I; Topo1; topoI; TopoI; topoisomerase I
Summary
Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in several processes, including chromosome organization; instar larval development; and regulation of embryonic development. Located in cytoplasm; euchromatin; and nucleolar chromatin. Is expressed in adult brain cell body rind; organism; and ovary. Orthologous to several human genes including TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Top1 in Genome Data Viewer
Location:
13B6-13B6; 1-50 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15319479..15328029)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15213512..15222062)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44429 Neighboring gene germ cell-expressed bHLH-PAS Neighboring gene antisense RNA:CR44961 Neighboring gene mir-4957 stem loop Neighboring gene discontinuous actin hexagon Neighboring gene antisense RNA:CR44998 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic localization of DNA topoisomerase I and its functional relevance during Drosophila development. Huang W, et al. G3 (Bethesda), 2021 Sep 6. PMID 34544118, Free PMC Article
  2. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. Balasubramanyam K, et al. J Biol Chem, 2004 Aug 6. PMID 15155757
  3. Reverse gyrase functions as a DNA renaturase: annealing of complementary single-stranded circles and positive supercoiling of a bubble substrate. Hsieh TS, et al. J Biol Chem, 2006 Mar 3. PMID 16407212
  4. The phosphoCTD-interacting domain of Topoisomerase I. Wu J, et al. Biochem Biophys Res Commun, 2010 Jun 18. PMID 20493173, Free PMC Article
  5. Chromatin structural transitions in Drosophila embryo cell-free extract result in a high conformational flexibility of nucleosomal DNA. Krajewski WA. FEBS Lett, 1999 Jun 11. PMID 10386593

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic localization of DNA topoisomerase I and its functional relevance during Drosophila development.
    Title: Dynamic localization of DNA topoisomerase I and its functional relevance during Drosophila development.
  2. B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
    Title: The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.
  3. In a model of human epilepsy, topo I shows a novel function in construction and/or maintenance of circuits required for seizure propagation in vivo.
    Title: Seizure suppression by top1 mutations in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 15326740-15326927 mobile_element_type = transposon:I{}137

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in instar larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolar chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
topoisomerase 1
Names
CG6146-PA
CG6146-PB
CG6146-PC
CG6146-PD
CG6146-PE
Top 1
Top1-PA
Top1-PB
Top1-PC
Top1-PD
Top1-PE
topoisomerase I
topoisomerase1
type I topoisomerase
NP_001014742.1
NP_001245679.1
NP_001285267.1
NP_511161.2
NP_727841.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15319479..15328029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078606.4 → NP_511161.2  topoisomerase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511161.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30189, Q9VXW6
    UniProtKB/TrEMBL
    Q494M1
    Related
    FBpp0073822
    Conserved Domains (4) summary
    smart00435
    Location:585 → 946
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:441 → 655
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:657 → 859
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:905 → 972
    Topo_C_assoc; C-terminal topoisomerase domain

  2. NM_001014742.2 → NP_001014742.1  topoisomerase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30189, Q9VXW6
    UniProtKB/TrEMBL
    Q494M1
    Conserved Domains (4) summary
    smart00435
    Location:585 → 946
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:441 → 655
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:657 → 859
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:905 → 972
    Topo_C_assoc; C-terminal topoisomerase domain

  3. NM_001258750.2 → NP_001245679.1  topoisomerase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245679.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30189, Q9VXW6
    UniProtKB/TrEMBL
    M9NDX3
    Conserved Domains (4) summary
    smart00435
    Location:581 → 942
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:437 → 651
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:653 → 855
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:901 → 968
    Topo_C_assoc; C-terminal topoisomerase domain

  4. NM_167435.3 → NP_727841.1  topoisomerase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TPA7, Q8IR39
    Related
    FBpp0073823
    Conserved Domains (4) summary
    smart00435
    Location:192 → 553
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:48 → 262
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:264 → 466
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:512 → 579
    Topo_C_assoc; C-terminal topoisomerase domain

  5. NM_001298338.1 → NP_001285267.1  topoisomerase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TPA7, X2JKD2
    Conserved Domains (4) summary
    smart00435
    Location:204 → 565
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:60 → 274
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:276 → 478
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:524 → 591
    Topo_C_assoc; C-terminal topoisomerase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDX3 M9NDX3
P30189.1 P30189
Q494M1 Q494M1
Q8IR39 Q8IR39
X2JKD2 X2JKD2

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