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shtd shattered [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32473, updated on 4-Jan-2025

Summary

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Official Symbol
shtdprovided by FlyBase
Official Full Name
shatteredprovided by FlyBase
Primary source
FLYBASE:FBgn0004391
Locus tag
Dmel_CG9198
See related
AllianceGenome:FB:FBgn0004391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Apc1; APC1; APC1/shtd; CG9198; Dmel\CG9198; Shtd; SHTD
Summary
Predicted to enable molecular adaptor activity. Involved in anaphase-promoting complex-dependent catabolic process and compound eye development. Part of anaphase-promoting complex. Is expressed in cephalic furrow; eye disc; eye disc morphogenetic furrow; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See shtd in Genome Data Viewer
Location:
13C3-13C4; 1-50 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15455544..15462441, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15349577..15356474, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene scamp Neighboring gene Adenosylhomocysteinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip128

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment. Défachelles L, et al. J Cell Sci, 2015 Mar 15. PMID 25616898, Free PMC Article
  2. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. Whitfield ZJ, et al. PLoS Biol, 2013 Sep. PMID 24019759, Free PMC Article
  3. Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis. Garrido D, et al. PLoS Genet, 2020 Nov. PMID 33137813, Free PMC Article
  4. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841
  5. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Mohd-Sarip A, et al. Science, 2012 May 11. PMID 22491092

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. shtd encodes Apc1; reducing the dosage of either CycA or stg suppressed the shtd1 phenotype.
    Title: Mutation of the Apc1 homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle HMP PubMed 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of anaphase-promoting complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
shattered
Names
CG9198-PA
shtd-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15455544..15462441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132797.3 → NP_573025.2  shattered [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573025.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXV3
    Related
    FBpp0073893
    Conserved Domains (1) summary
    pfam12859
    Location:195 → 298
    ANAPC1; Anaphase-promoting complex subunit 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q960S7 Q960S7
Q9VXV3 Q9VXV3

Gene LinkOut

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