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Ac13E Adenylyl cyclase 13E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32485, updated on 9-Dec-2024

Summary

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Official Symbol
Ac13Eprovided by FlyBase
Official Full Name
Adenylyl cyclase 13Eprovided by FlyBase
Primary source
FLYBASE:FBgn0022710
Locus tag
Dmel_CG9210
See related
AllianceGenome:FB:FBgn0022710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 13E; ac13e; AC13E; Ac35C; CG9210; DAC9; dADCY9; Dmel\CG9210
Summary
Enables adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ac13E in Genome Data Viewer
Location:
13C7-13D2; 1-50 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15510877..15554278, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15404910..15448311, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Golgi microtubule-associated protein Neighboring gene mir-304 stem loop Neighboring gene mir-12 stem loop Neighboring gene long non-coding RNA:CR44353 Neighboring gene long non-coding RNA:CR44354 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX. Iourgenko V, et al. FEBS Lett, 1997 Aug 11. PMID 9287125
  2. A calcium-inhibited Drosophila adenylyl cyclase. Iourgenko V, et al. Biochim Biophys Acta, 2000 Feb 2. PMID 10656970
  3. A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. Yovell Y, et al. J Neurochem, 1992 Nov. PMID 1402918
  4. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
  5. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenylyl cyclase 13E
Names
Ac13E-PA
Ac13E-PB
Ac13E-PC
CG9210-PA
CG9210-PB
CG9210-PC
adenyly cyclase 35C
adenylyl cyclase
adenylyl cyclase 35C
NP_001014745.1
NP_001259575.1
NP_477299.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15510877..15554278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014745.2 → NP_001014745.1  adenylyl cyclase 13E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16039, Q9VXU0
    Conserved Domains (2) summary
    smart00044
    Location:289 → 505
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:348 → 522
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

  2. NM_001272646.2 → NP_001259575.1  adenylyl cyclase 13E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEP2, O16039
    Conserved Domains (2) summary
    smart00044
    Location:302 → 518
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:361 → 535
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

  3. NM_057951.3 → NP_477299.1  adenylyl cyclase 13E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16039, Q9VXU0
    Related
    FBpp0073889
    Conserved Domains (2) summary
    smart00044
    Location:289 → 505
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:348 → 522
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEP2 M9PEP2
O16039 O16039
Q9VXU0 Q9VXU0

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