znf503 zinc finger protein 503 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znf503provided by ZNC
Official Full Name: zinc finger protein 503provided by ZNC
Primary source: ZFIN:ZDB-GENE-031113-5
See related: Ensembl:ENSDARG00000018492 AllianceGenome:ZFIN:ZDB-GENE-031113-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nlz2; noz2; fc47h01; wu:fc47h01; wu:fi34f11
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within embryonic camera-type eye morphogenesis and hindbrain development. Located in nucleus. Is expressed in several structures, including external yolk syncytial layer; mesoderm; nervous system; neural tube; and optic cup. Orthologous to human ZNF503 (zinc finger protein 503). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (17468466..17471044)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (17337474..17340052)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure
Title: Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
nlz2 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary,where expression of nlz1 is dependent on pax2a.
Title: nlz gene family is required for hindbrain patterning in the zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc47h01 (e-PCR)
- UniSTS:189216

fd05f08.y1 (e-PCR)
- UniSTS:194966

fi34f11.x1 (e-PCR)
- UniSTS:197348

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger protein 503

Names: nocA related zinc finger 2; nocA-like zinc finger protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198840.3 → NP_942137.1 zinc finger protein 503

See identical proteins and their annotated locations for NP_942137.1

Status: PROVISIONAL

Source sequence(s)

BC044193

UniProtKB/Swiss-Prot

Q6UFS5, Q803U2

UniProtKB/TrEMBL

B2GRW1

Related

ENSDARP00000019426.4, ENSDART00000008906.5

Conserved Domains (2) summary

sd00017
Location:433 → 459

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12402
Location:295 → 342

nlz1; NocA-like zinc-finger protein 1