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Chc Clathrin heavy chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32537, updated on 4-Jan-2025

Summary

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Official Symbol
Chcprovided by FlyBase
Official Full Name
Clathrin heavy chainprovided by FlyBase
Primary source
FLYBASE:FBgn0000319
Locus tag
Dmel_CG9012
See related
AllianceGenome:FB:FBgn0000319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9012; chc; CHC; chc1; Cla; Clh; CLH; D-Chc; dCHC; Dmel\CG9012; l(1)13Fb; l(1)G0438; l(1)VI
Summary
Predicted to enable clathrin light chain binding activity. Involved in several processes, including compound eye retinal cell programmed cell death; germ cell development; and open tracheal system development. Located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle; and trans-Golgi network. Is expressed in several structures, including adult head; epidermis; gland; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Chc in Genome Data Viewer
Location:
13F5-13F7; 1-52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15827986..15835490, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15722019..15729523, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44384 Neighboring gene scalloped Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR32582 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synaptic endocytosis: illuminating the role of clathrin assembly. Rodal AA, et al. Curr Biol, 2008 Mar 25. PMID 18364232
  2. Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1. Jacquemyn J, et al. NPJ Parkinsons Dis, 2023 Feb 4. PMID 36739293, Free PMC Article
  3. Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval. Kasprowicz J, et al. J Cell Biol, 2014 Mar 31. PMID 24662566, Free PMC Article
  4. Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation. Venken KJ, et al. Nucleic Acids Res, 2008 Oct. PMID 18676454, Free PMC Article
  5. The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism. Bazinet C, et al. Genetics, 1993 Aug. PMID 8375651, Free PMC Article

See all (195) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex.
    Title: Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D.
  2. Results report a Drosophila disabled (DAB)mutant revealing a novel role for DAB proteins in chemical synaptic transmission, and support a role for clathrin-mediated endocytosis in rapid clearance of neurotransmitter release sites.
    Title: The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone.
  3. Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
    Title: Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
  4. chc mRNA and protein are highly expressed from early stages of embryogenesis onwards, consistent with genetic studies predicting a maternal contribution of the gene function
    Title: Expression and localization of clathrin heavy chain in Drosophila melanogaster.
  5. Chc is critical for synaptic vesicle recycling and in the absence of the protein, bulk retrieval mediates massive synaptic membrane internalization.
    Title: Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin light chain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secretory granule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
clathrin heavy chain
Names
CG9012-PA
CG9012-PB
CG9012-PC
CG9012-PD
CG9012-PE
CG9012-PF
CG9012-PG
Chc-PA
Chc-PB
Chc-PC
Chc-PD
Chc-PE
Chc-PF
Chc-PG
clathrin
clathrin hc
clathrin heavy-chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15827986..15835490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103524.2 → NP_001096994.1  clathrin heavy chain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  2. NM_001103523.2 → NP_001096993.1  clathrin heavy chain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  3. NM_057694.3 → NP_477042.1  clathrin heavy chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0073966
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  4. NM_001298371.1 → NP_001285300.1  clathrin heavy chain, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285300.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  5. NM_206729.2 → NP_996452.1  clathrin heavy chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  6. NM_206728.2 → NP_996451.1  clathrin heavy chain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link

  7. NM_167466.2 → NP_727901.1  clathrin heavy chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742, Q540W2, Q9VXN6
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0073967
    Conserved Domains (5) summary
    smart00299
    Location:1275 → 1417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:984 → 1120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256 → 288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 422
    Clathrin_H_link; Clathrin-H-link
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29742.1 P29742
X2JC31 X2JC31

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