Lcch3 Ligand-gated chloride channel homolog 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lcch3provided by FlyBase
Official Full Name: Ligand-gated chloride channel homolog 3provided by FlyBase
Primary source: FLYBASE:FBgn0010240
Locus tag: Dmel_CG17336
See related: AllianceGenome:FB:FBgn0010240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17336; CT38330; Dmel\CG17336; DmGABAbeta; DmGA_b; LCCH3
Summary: Enables GABA-gated chloride ion channel activity. Predicted to be involved in chloride transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe local neurons; adult central brain; adult optic lobe; ganglia; and larval nervous system. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; autistic disorder; epilepsy (multiple); and heroin dependence. Orthologous to several human genes including GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1) and GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15925105..15928529)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15819138..15822562)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG17336-PC; GABA receptor beta subunit; Lcch3-PC; beta subunit; ligand-gated chloride channel; ligand-gated chloride channel homologue 3

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The following sections contain reference sequences that belong to a specific genome build. Explain