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ND-20 NADH dehydrogenase (ubiquinone) 20 kDa subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32565, updated on 9-Dec-2024

Summary

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Official Symbol
ND-20provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) 20 kDa subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0030718
Locus tag
Dmel_CG9172
See related
AllianceGenome:FB:FBgn0030718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
20 kDa; CG9172; Dmel\CG9172; Dmel_CG9172; dNDUFS7; dNDUFS7A; ND20; NDUFS7; NUKM; PSST
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including determination of adult lifespan; mitochondrial respiratory chain complex I assembly; and regulation of terminal button organization. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex I deficiency and nuclear type mitochondrial complex I deficiency 3. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ND-20 in Genome Data Viewer
Location:
14A5-14A5; 1-52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15985473..15986808, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15879506..15880841, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene Solute carrier family 25 member 46a Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene extradenticle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model. Christen M, et al. Sci Rep, 2024 Feb 5. PMID 38316835, Free PMC Article
  2. A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urticae is associated with resistance to METI acaricides. Bajda S, et al. Insect Biochem Mol Biol, 2017 Jan. PMID 27919778
  3. RNAi of Complex I and V of the electron transport chain in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster. Landis JE, et al. PLoS One, 2023. PMID 37319260, Free PMC Article
  4. Drosophila Prominin-like, a homolog of CD133, interacts with ND20 to maintain mitochondrial function. Wang X, et al. Cell Biosci, 2019. PMID 31890150, Free PMC Article
  5. A Drosophila Mitochondrial Complex I Deficiency Phenotype Array. Foriel S, et al. Front Genet, 2019. PMID 30972103, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) 20 kDa subunit
Names
CG9172-PA
CG9172-PB
CG9172-PC
FBpp0073949
NADH ubiquinone oxidoreductase 20 kDa
NADH-UBIQUINONE OXIDOREDUCTASE 20 KDA SUBUNIT
NADH:ubiquinone oxidoreductase 20 kDa subunit
ND-20-PA
ND-20-PB
ND-20-PC
NP_001285313.1
NP_573097.1
NP_727921.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15985473..15986808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298384.1 → NP_001285313.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285313.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXK7
    Conserved Domains (1) summary
    PRK06411
    Location:72 → 213
    PRK06411; NADH dehydrogenase subunit B; Validated

  2. NM_132869.4 → NP_573097.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXK7
    Related
    FBpp0073949
    Conserved Domains (1) summary
    PRK06411
    Location:72 → 213
    PRK06411; NADH dehydrogenase subunit B; Validated

  3. NM_167476.2 → NP_727921.1  NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXK7
    Related
    FBpp0073950
    Conserved Domains (1) summary
    PRK06411
    Location:72 → 213
    PRK06411; NADH dehydrogenase subunit B; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXK7 Q9VXK7

Gene LinkOut

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