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eIF5 eukaryotic translation initiation factor 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32566, updated on 4-Jan-2025

Summary

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Official Symbol
eIF5provided by FlyBase
Official Full Name
eukaryotic translation initiation factor 5provided by FlyBase
Primary source
FLYBASE:FBgn0030719
Locus tag
Dmel_CG9177
See related
AllianceGenome:FB:FBgn0030719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe3C6; CG9177; Dmel\CG9177; EIf5; EIF5
Summary
Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Predicted to be involved in formation of cytoplasmic translation initiation complex. Predicted to be active in cytosol. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and germline cell. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See eIF5 in Genome Data Viewer
Location:
14A5-14A5; 1-52 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15987008..15991974, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15881041..15886007, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Solute carrier family 25 member 46a Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit Neighboring gene uncharacterized protein Neighboring gene extradenticle Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS. Gotoh S, et al. J Biol Chem, 2024 Mar. PMID 38301895, Free PMC Article
  2. Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex. Li Z, et al. Stem Cell Res Ther, 2022 Jul 26. PMID 35883200, Free PMC Article
  3. The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Lee S, et al. Development, 2007 May. PMID 17409115
  4. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article
  5. Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Chew SK, et al. Nature, 2009 Jul 2. PMID 19483676, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 5
Names
CG9177-PA
CG9177-PB
CG9177-PC
CG9177-PD
CG9177-PE
CG9177-PF
CG9177-PG
anon-fast-evolving-3C6
eIF5-PA
eIF5-PB
eIF5-PC
eIF5-PD
eIF5-PE
eIF5-PF
eIF5-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15987008..15991974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206757.2 → NP_996480.1  eukaryotic translation initiation factor 5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  2. NM_206756.2 → NP_996479.1  eukaryotic translation initiation factor 5, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996479.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  3. NM_167477.2 → NP_727922.1  eukaryotic translation initiation factor 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Related
    FBpp0073947
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  4. NM_206755.2 → NP_996478.1  eukaryotic translation initiation factor 5, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996478.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  5. NM_132870.4 → NP_573098.1  eukaryotic translation initiation factor 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573098.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Related
    FBpp0073948
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  6. NM_206758.2 → NP_996481.1  eukaryotic translation initiation factor 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  7. NM_206754.2 → NP_996477.1  eukaryotic translation initiation factor 5, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4K0, Q0KHS2, Q9VXK6
    Conserved Domains (2) summary
    cd11561
    Location:254 → 408
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:10 → 127
    eIF-5_eIF-2B; Domain found in IF2B/IF5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXK6.1 Q9VXK6

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