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CG3632 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32589, updated on 9-Dec-2024

Summary

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Official Symbol
CG3632provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030735
Locus tag
Dmel_CG3632
See related
AllianceGenome:FB:FBgn0030735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3632; MTMR3/4
Summary
Predicted to enable phosphatase activity and protein phosphatase binding activity. Involved in negative regulation of BMP signaling pathway. Predicted to be active in cytoplasm and membrane. Is expressed in organism. Orthologous to several human genes including MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG3632 in Genome Data Viewer
Location:
14B9-14B9; 1-53 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16296671..16303308)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16190704..16197341)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene cabeza Neighboring gene Endoplasmic reticulum protein 44 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. Oppelt A, et al. EMBO Rep, 2013 Jan. PMID 23154468, Free PMC Article
  2. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
  3. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. Yu J, et al. J Biol Chem, 2013 Jan 4. PMID 23150675, Free PMC Article
  4. PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase. Ghosh A, et al. Life Sci Alliance, 2023 Sep. PMID 37316298, Free PMC Article
  5. The Exon Junction Complex and intron removal prevent re-splicing of mRNA. Joseph B, et al. PLoS Genet, 2021 May. PMID 34033644, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling
    Title: Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3632-PE
CG3632-PF
CG3632-PG
CG3632-PH
CG3632-PI
CG3632-PJ
MYOTUBULARIN-like
NP_001096996.1
NP_001096997.1
NP_001096998.1
NP_001096999.1
NP_727950.3
NP_727952.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16296671..16303308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167497.3 → NP_727950.3  uncharacterized protein Dmel_CG3632, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727950.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV04
    Conserved Domains (3) summary
    cd15733
    Location:1153 → 1212
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:212 → 581
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:26 → 138
    PH-like; Pleckstrin homology-like domain

  2. NM_167499.3 → NP_727952.3  uncharacterized protein Dmel_CG3632, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727952.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GPV6
    Conserved Domains (2) summary
    pfam06602
    Location:212 → 581
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:26 → 138
    PH-like; Pleckstrin homology-like domain

  3. NM_001103529.3 → NP_001096999.1  uncharacterized protein Dmel_CG3632, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096999.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV04
    Conserved Domains (3) summary
    cd15733
    Location:1153 → 1212
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:212 → 581
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:26 → 138
    PH-like; Pleckstrin homology-like domain

  4. NM_001103528.3 → NP_001096998.1  uncharacterized protein Dmel_CG3632, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096998.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV04
    Conserved Domains (3) summary
    cd15733
    Location:1153 → 1212
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:212 → 581
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:26 → 138
    PH-like; Pleckstrin homology-like domain

  5. NM_001103526.3 → NP_001096996.1  uncharacterized protein Dmel_CG3632, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096996.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU03
    Conserved Domains (3) summary
    cd15733
    Location:1162 → 1221
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:221 → 590
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:35 → 147
    PH-like; Pleckstrin homology-like domain

  6. NM_001103527.2 → NP_001096997.1  uncharacterized protein Dmel_CG3632, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096997.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV04
    Conserved Domains (3) summary
    cd15733
    Location:1153 → 1212
    FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
    pfam06602
    Location:212 → 581
    Myotub-related; Myotubularin-like phosphatase domain
    cl17171
    Location:26 → 138
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GPV6 A0A023GPV6
A8JV04 A8JV04
Q7YU03 Q7YU03

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